Patents Assigned to St. Jude Childen's Research Hospital
  • Methods of effecting Wnt signaling through Dkk structural analysis
    Patent number: 8716243
    Abstract: Compositions and methods related to Wnt signaling regulation by Dickkopf (Dkk) polypeptides and Wnt-related diseases are disclosed. For example, compounds that bind a Dkk or LRP polypeptide are disclosed. Compounds that disrupt binding of a Dkk polypeptide to an LRP polypeptide are also disclosed. Methods for using the described compounds and compositions are also disclosed.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: May 6, 2014
    Assignee: St. Jude Childen's Research Hospital
    Inventor: Jie Zheng