Abstract: An imaging system includes a display, an x-ray based image acquisition device, a workstation, and a medical device, e.g., a catheter. The image acquisition device is configured to obtain real-time two-dimensional images of a portion of a patient's body that is disposed within the field of view of the image acquisition device. The workstation is configured to integrate and register a three-dimensional model of an anatomic structure with the two-dimensional image, and to provide the display with a real-time image of the integrated image. The catheter includes a distal portion that comprises a radiopaque material. The image acquisition device is further adapted to apply radiation at a first dosage rate that is below a second dosage rate sufficient to detect anatomic structures.