Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for performing intravascular data analysis and measurement of various types of data such as pressure and flow data. The disclosure relates to probes and methods suitable for determining an event in a cardiac cycle such as flow threshold such as a peak flow, a fraction thereof, other intravascular parameters or a point in time during which peak flow or a change in one of the parameters occurs. An exemplary probe includes one or more of a pressure sensor, a resistor, a flow sensor and can be used to generate diagnostic data based upon measured intravascular and other parameters. In part, the disclosure relates to methods and systems suitable for determining a coronary flow reserve value in response to one or more of intravascular pressure and flow data or data otherwise correlated therewith.

Abstract: A sensor guide wire assembly having a button-cell type battery includes a transmitter unit configured to be connected to a sensor guide wire that is insertable into a patient to measure a parameter, the transmitter unit being configured to wirelessly transfer data representing the measured parameter to a communication unit. The transmitter unit includes a housing, a printed circuit board holder disposed in the housing, and a printed circuit board disposed in the housing and held by the printed circuit board holder. The printed circuit board includes a plurality of electrical contacts. A slider is slidable from a location outside the housing, the slider including a protrusion extending into an area inside the housing. A space within the housing is configured to hold one or more batteries.

Abstract: The present application relates to a radio opaque material and a method of producing the same. The material is a hybrid material comprising two phases, an inorganic phase comprising a radio opaque substance and a polymer phase.

Abstract: A male connector for a sensor guide wire for intravascular measurements of physiological variables in a living body, and a method for producing said male connector. The male connector comprises a plurality of spaced apart conductive members, extending at least partially along the length of the male connector, and a plurality of conductive areas separated from each other by insulating areas, disposed along the male connector, wherein each of the conductive members are connected to a respective conductive area.

Abstract: An active noise cancellation device (2) for a medical device includes an active circuit having a first input connection (8), a second input connection (10), and an output connection (12). The second input connection (10) is connected to at least one predetermined reference signal. The active noise cancellation device (2) further includes a low-impedance body connection electrode (4) adapted to be in electrical contact with a bloodstream of a subject, wherein the low-impedance body connection electrode (4) is connected to said first input connection (8), and a feedback branch (14) connecting the output connection (12) with the first input connection (8). The feedback branch (14) comprises a current limiting circuit (18) to limit a current through said feedback branch (14) to be lower than a predetermined current.

Abstract: Sensor guide wire for intravascular measurements of physiological variables in a living body or of external signals, which sensor guide wire has a proximal region, a distal sensor region and a tip region, the sensor guide wire comprises a core wire having a longitudinal axis parallel to the longitudinal axis of the sensor guide wire, and a sensor element arranged in the distal sensor region, the sensor element has a sensitive portion for measuring the physiological variable and to generate a sensor signal in response to said variable. The sensor element has an essentially planar main surface and has its maximal extension in the plane of the main surface, and a thickness perpendicular to the plane of the main surface, wherein the sensor element is arranged in an essentially perpendicular relation to said core wire with regard to the planar main surface of the sensor element.

Abstract: Described herein are methods of forming hydrogels comprising combining (a) a water-soluble polymer comprising thiol groups, and (b) a water-soluble metal salt in an aqueous solution. The hydrogels form rapidly. Hydrogels and related methods, uses, and products also are described.

Abstract: A composite material for a medical implant includes a matrix of magnesium or magnesium alloy, and a catalyst which is dispersed within the matrix. The catalyst has the capacity to reduce an amount of hydrogen gas released from the matrix when the matrix is being degraded inside the patient.

Abstract: A sensor guide wire for intravascular measurements of at least one physiological or other variable in a living body, comprising a proximal region, a distal sensor region, and a tip region, and at least one sensor element arranged in said sensor region and configured to measure the variable and to generate a sensor signal in response to the variable. The sensor guide wire further comprises a core wire, with a tip core wire portion, wherein at least part of the tip core wire portion comprises a shape memory material, and the composition of the shape memory material is such that the transformation temperature of the shape memory material is above the body temperature of the living body.

Abstract: A sensor guide wire for an intravascular measurement of a physiological variable in a living body may include a sensor element configured to measure the physiological variable based on exposure to fluid in the living body; and a cylindrical-shaped jacket forming an interior space housing the sensor element. The jacket comprises an outer circumferential wall with a circumferential surface extending between distal and proximal longitudinal ends of the jacket. The outer circumferential wall of the jacket does not include any apertures along its circumferential surface so as to prevent fluid from passing through the outer circumferential wall and/or the jacket has a constant cross section along its entire length.

Abstract: An interface to connect sensor equipment and a physiological monitor includes a first connector to receive power from a first channel of the monitor and a second connector to receive power from a second channel of the monitor. The power from each of the first and second channels of the monitor is combined within the interface. The interface further includes a third connector to provide the combined power to the sensor equipment; a voltage converter to rescale the voltage of the combined power that is provided to the sensor equipment; and a scaling circuit to reduce the voltage of a signal representing a measured physiological parameter. The signal representing the measured physiological parameter is sent from the sensor equipment to the monitor. The interface is advantageous to allow sensor equipment to be sufficiently powered by a monitor that would not typically provide enough power.

Abstract: A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and a sensor disposed within the insertable portion at a distal end of the senior wire. The sensor is configured to measure a parameter when inserted inside the patient. The transceiver unit may comprise: a housing adapted to be connected to a proximal end of the sensor wire; and a first communication module within the housing adapted to wirelessly communicate by a communication signal with an external second communication module in order to transfer information to the external second communication module.

Abstract: An insertion tool for a medical closure device for the sealing of an opening in a wall of a bodily organ includes a tamping force source adapted to deliver a first member to a position at the opening on one side of the wall subsequently to a second member being positioned at the opening on the opposite side of the wall. The tamping force source, which is energized prior to the tamping procedure, can be a spring, an elastic band or a pressurized gas container. A tamping spring can be compressed or extended upon loading. The tamping force source can be released in response to a manual operation or be triggered by retraction of the insertion tool.

Abstract: A measurement system may comprise a sensor wire, a sensor, and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body. The sensor is disposed within the insertable portion at a distal end of the sensor wire. The sensor is configured to measure or detect a non-physiological parameter when inserted inside the patient. The transceiver unit is adapted to generate a communication signal and to transfer information related to the non-physiological parameter to an external communication module using the communication signal. The communication signal includes sensor values related to the non-physiological parameter. The transceiver unit may comprise a housing adapted to be connected to a proximal end of the sensor wire and configured to remain external to the patient's body.

Abstract: Medical guide wire assembly comprising a guide wire having a proximal end and a distal end, at least one physiology parameter sensor, and that the proximal end of the guide-wire is provided with an elongated connector part, having connection electrodes, for insertion into a connector housing provided with an elongated tubing adapted to achieve electrical and mechanical connection to the elongated connector part, the connector housing is in its turn electrically or wirelessly connectable to a physiology monitor. The guide wire is provided with a core wire running essentially along the entire guide wire. A sensor signal processing circuitry is arranged in connection with the physiological sensor and is adapted to generate a processed sensor signal in response of a sensed parameter. The sensor signal processing circuitry comprises a modulation unit arranged to modulate the processed sensor signal and to generate a modulated sensor signal.

Abstract: Medical guide wire assembly comprising a guide wire having a proximal end and a distal end, at least one physiology parameter sensor, and that the proximal end of the guide-wire is provided with an elongated connector part, having connection electrodes, for insertion into a connector housing provided with an elongated tubing adapted to achieve electrical and mechanical connection to the elongated connector part, the connector housing is in its turn electrically or wirelessly connectable to a physiology monitor. The guide wire is provided with a core wire running essentially along the entire guide wire. A sensor signal processing circuitry is arranged in connection with the physiological sensor and is adapted to generate a processed sensor signal in response of a sensed parameter. The sensor signal processing circuitry comprises a modulation unit arranged to modulate the processed sensor signal and to generate a modulated sensor signal.

Abstract: There is a sensor guide wire (1) for intravascular measurements of physiological variables in a living body. The sensor guide wire (1) comprises at least two elongate sections, a first tubular elongate section (2) being tubular in the longitudinal direction of the sensor guide wire (1), and a second elongate section (3) that is adapted to be inserted a predetermined distance (5) into said first tubular section (2), a sensor element (10) provided in the distal part of said sensor guide wire (1), for measuring the physiological variable and to generate a sensor signal in response to said variable, at least one signal transmitting cable connected to the sensor element (10) to transmit sensor signals to a male connector provided in the proximal part of said sensor guide wire (1).

Abstract: A tube for an intravascular medical device has a longitudinal extension along a longitudinal axis. The tube comprises a tube wall having a specified thickness and a plurality of through-going slots, wherein each slot has an essentially elongated shape along a main extension extending along the circumference of the tube. At least two slots are provided in a plane perpendicular to the longitudinal axis such that the main extension of the at least two slots are in the perpendicular plane. The lengths of the slots in the same perpendicular plane P are essentially the same, and the lengths L of the slots in different planes vary along the longitudinal extension of the tube according to a predefined pattern. A sensor guide wire for an intravascular measurement of at least one variable in a living body may comprise such a tube.

Abstract: Sensor guide wire for intravascular measurements of a physiological variable in a living body, comprising a core wire running along at least a part of the sensor guide wire and a sensor element arranged in a jacket in a sensor region of the sensor guide wire. The jacket is tubular and is provided with a jacket wall and a portion of the core wire that extends longitudinally along the sensor region forms part of the wall of the jacket, in order to provide more space in the jacket.

Abstract: A sensor guide wire for an intravascular measurement of at least one physiological or other variable in a living body may have a proximal region, a distal sensor region, and a tip region. The sensor guide wire may further comprise a sensor clement arranged in the sensor region, and comprising a sensor portion for measuring the variable and to generate a sensor signal in response to the variable. Furthermore, a core wire, having a longitudinal axis A, and comprising at least a tip core wire portion, extends essentially along the tip region of the sensor guide wire. The tip core wire portion may further comprise a distal tip. At least a major part of the tip core wire portion is provided with a polymer layer essentially enclosing the at least major part. The distal tip of the tip core wire portion may further comprise an enlargement.