Patents Assigned to St. Louis University Health Sciences Center
  • Antibody of the anti-proliferation domain of human Bcl-2
    Patent number: 6207452
    Abstract: A domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO:13) of Bcl-2. Peptides including the domain and nucleotides encoding the domain are useful in molecular screening of human tumors for the presence of mutations that allow proliferation of cells that were otherwise marked for apoptosis. The peptides are also useful to screen for proteins that play a role in the modulation of cellular proliferation.
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: March 27, 2001
    Assignee: St. Louis University Health Sciences Center
    Inventor: Chinnadurai Govindaswamy
  • Screens for mutations in the anti-proliferation domain of human Bcl-2
    Patent number: 5952179
    Abstract: A domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO: 13) of Bcl-2. Peptides including the domain and nucleotides encoding the domain are useful in molecular screening of human tumors for the presence of mutations that allow proliferation of cells that were otherwise marked for apoptosis. The peptides are also useful to screen for proteins that play a role in the modulation of cellular proliferation.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: September 14, 1999
    Assignee: St. Louis University Health Sciences Center
    Inventor: Govindaswamy Chinnadurai
  • Anti-proliferation domain of a human Bcl-2 and DNA encoding the same
    Patent number: 5821082
    Abstract: A domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO:13) of Bcl-2. Peptides including the domain and nucleotides encoding the domain are useful in molecular screening of human tumors for the presence of mutations that allow proliferation of cells that were otherwise marked for apoptosis. The peptides are also useful to screen for proteins that play a role in the modulation of cellular proliferation.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: October 13, 1998
    Assignee: St. Louis University Health Sciences Center
    Inventor: Govindaswamy Chinnadurai