Abstract: In some embodiments, the present disclosure pertains to a method of delivery of an active agent to a target tissue, in a subject in need thereof comprising positioning a high intensity focused ultrasound transducer to enable delivery of ultrasound energy to the target tissue. Such a method comprises energizing the high intensity focused ultrasound transducer; imaging at least a portion of the target tissue; and discontinuing delivery of ultrasound energy. Further, such a method may comprise administering the active agent to the subject under the conditions of thermal stimulation. In another embodiment, the present disclosure relates to a method of treating a tumor in a subject in need thereof comprising administering a therapeutic agent to the subject and providing thermal stimulation to the tumor. In some embodiments, there is provided a method for increasing the efficacy of a therapeutic agent in a target tissue.
Type:
Application
Filed:
August 30, 2019
Publication date:
December 19, 2019
Applicants:
University of Houston System, St. Luke's Episcopal Hospital
Inventors:
Pei-Herng Hor, Raja Muthupillai, Jiming Zhang
Abstract: In some embodiments, the present disclosure pertains to a method of delivery of an active agent to a target tissue, in a subject in need thereof comprising positioning a high intensity focused ultrasound transducer to enable delivery of ultrasound energy to the target tissue. Such a method comprises energizing the high intensity focused ultrasound transducer; imaging at least a portion of the target tissue; and discontinuing delivery of ultrasound energy. Further, such a method may comprise administering the active agent to the subject under the conditions of thermal stimulation. In another embodiment, the present disclosure relates to a method of treating a tumor in a subject in need thereof comprising administering a therapeutic agent to the subject and providing thermal stimulation to the tumor. In some embodiments, there is provided a method for increasing the efficacy of a therapeutic agent in a target tissue.
Type:
Grant
Filed:
May 6, 2013
Date of Patent:
October 15, 2019
Assignees:
UNIVERSITY OF HOUSTON, ST. LUKE'S EPISCOPAL HOSPITAL
Inventors:
Pei-Herng Hor, Raja Muthupillai, Jiming Zhang
Abstract: In some embodiments, the present disclosure pertains to a method of delivery of an active agent to a target tissue, in a subject in need thereof comprising positioning a high intensity focused ultrasound transducer to enable delivery of ultrasound energy to the target tissue. Such a method comprises energizing the high intensity focused ultrasound transducer; imaging at least a portion of the target tissue; and discontinuing delivery of ultrasound energy. Further, such a method may comprise administering the active agent to the subject under the conditions of thermal stimulation. In another embodiment, the present disclosure relates to a method of treating a tumor in a subject in need thereof comprising administering a therapeutic agent to the subject and providing thermal stimulation to the tumor. In some embodiments, there is provided a method for increasing the efficacy of a therapeutic agent in a target tissue.
Type:
Application
Filed:
May 6, 2013
Publication date:
November 28, 2013
Applicants:
St. Luke's Episcopal Hospital, University of Houston
Inventors:
Pei-Herng Hor, Raja Muthupillai, Jiming Zhang
Abstract: A low-bulk gas delivering apparatus for use in a catheter laboratory is provided. The apparatus includes a universally articulatable support arm, one end of which is adapted to mount onto a ceiling and the other end of which is mounted to a gas module. The gas module is adapted to deliver gas received from a hose which connects the gas module to a source of gas. The hose generally extends along the support arm and is disposed outside of the support arm. Therefore, the support arm is lighter, slimmer, and less bulky than previously used support arms.
Type:
Grant
Filed:
October 25, 1989
Date of Patent:
May 14, 1991
Assignee:
St. Luke's Episcopal Hospital
Inventors:
William B. Wright, II, Dean D. Sauberli