Abstract: A bioreactor system for growing and conditioning tissue for research and implantation in a human or animal body is disclosed which includes one or more tissue growth chambers for growing and conditioning tissue, each chamber being defined by a housing and providing a fluid culture media cavity which can act as a reservoir. A construct for growing three-dimensional tissues is housed in each tissue growth chamber. Each chamber is connected to a source of pressurized air for applying a controlled pressure to the chamber media cavity. The tissue growth chambers can be mounted on an agitation device such as a shaker system which enhances mass transport within the chamber media cavity. A control system is provided to control the pressure and temperature of the pressurized gas delivered to the chamber media cavity and subsequently to the tissue construct.
Type:
Grant
Filed:
October 24, 2008
Date of Patent:
August 9, 2016
Assignee:
ST3 Development Corporation
Inventors:
Kent S. Vilendrer, Blaise D. Porter, Philippe Levesque
Abstract: A microprocessor controlled and instrumented bioreactor for conditioning tissue engineered medical products. The microprocessor control providing measurement and control of the tissue displacement and subsequent determination of material and growth properties. The microprocessor control providing adaptive adjustment of the applied conditions to provide optimal tissue growth.
Abstract: A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing measurement and control of the fluid flow and tissue displacement and subsequent determination of material properties. One design includes a flexible joint providing motion of the treated tissue in the axial, bending and torsional direction.