Abstract: A composition for preventing or treating a TNF-?-related disease is disclosed. The composition includes hydroflumethiazide or a pharmaceutically acceptable salt thereof as an active ingredient. The composition can effectively inhibit the expression or activity of TNF-? and exhibits an excellent treatment effect compared to methotrexate (MTX) or hydroxychloroquine (HCQ), which are rheumatoid arthritis treatment agents currently on the market, and, thus, can be effectively used for prevention or treatment of a TNF-?-related disease.
Type:
Application
Filed:
November 5, 2021
Publication date:
December 28, 2023
Applicants:
SK CHEMICALS CO., LTD., STANDIGM INC
Inventors:
Soo Min LEE, Jong-ln KIM, Nam-Jin GU, Jeong-Hoon KIM, Dae Hee HAN, Hee Jung KOO