Patents Assigned to Stanford University Board of Trustees
  • Patent number: 6500960
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of the formula wherein A is a moiety that activates the diketide, and at least one of R1 and R2 is a substituent other than that natively occurring in the diketide normally processed by the modified PKS cluster. The polyketides may also be glycosylated to provide antibiotics.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: December 31, 2002
    Assignees: Stanford University (Board of Trustees of the Leland Stanford Junior University), Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
  • Patent number: 6436903
    Abstract: Compounds having immunomodulatory activity which are peptide-type compounds, or variants or fragments thereof, including the N-terminal acylated and C-terminal amidated or esterified forms of up to 30 amino acids wherein the peptide-type compound comprises the formula: (a) R aa76-77 L aa79-84 or (b) aa84-79 L aa77-76 R wherein: aa76 is E or V; aa77 is D, S or N; aa79 is R or G; aa80 is I or N; aa81 is a small or hydrophobic amino acid aa82 is R or L; aa83 is G or R; aa84 is a small or hydrophobic amino acid; wherein, in said compounds, at least one of the amino acids is the D isomer are used by themselves or in combination with immunosuppressant drugs, to reduce CTL activation, particularly in association with transplantation.
    Type: Grant
    Filed: May 22, 1996
    Date of Patent: August 20, 2002
    Assignee: Stanford University (Board of Trustees of the Leland Standford Junior University)
    Inventors: Carol A. Clayberger, Alan M. Krensky
  • Patent number: 4267732
    Abstract: An acoustic apparatus and method for microscopic imaging and spectroscopy. The apparatus includes a plurality of devices for exciting an object of interest so that acoustic waves are propagated from the object. These devices include lasers, x-ray sources, microwave generators, ultraviolet sources, and electric current generators. The acoustic waves propagated from the object of interest are detected and the object of interest and the acoustic wave detector are moved with respect to each other in a raster scanning pattern. The magnitude of the detected acoustic waves and the corresponding raster pattern of the object are recorded so that a visual image of the object can be obtained. In addition, the frequency of the exciting electromagnetic radiation that excites the object can be varied so that both the absorption spectra and the Raman frequency mode of the object can be determined.
    Type: Grant
    Filed: November 29, 1978
    Date of Patent: May 19, 1981
    Assignee: Stanford University Board of Trustees
    Inventor: Calvin F. Quate