Patents Assigned to Stanford University (Board of Trustees of the Leland Stanford Junior University)
  • Method to produce novel polyketides
    Patent number: 6500960
    Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of the formula wherein A is a moiety that activates the diketide, and at least one of R1 and R2 is a substituent other than that natively occurring in the diketide normally processed by the modified PKS cluster. The polyketides may also be glycosylated to provide antibiotics.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: December 31, 2002
    Assignees: Stanford University (Board of Trustees of the Leland Stanford Junior University), Brown University Research Foundation
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao