Abstract: Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any other amino acid. Pharmaceutical compositions of the peptide analogues are provided. In addition, the peptide analogues are administered to patients with multiple sclerosis.
Type:
Application
Filed:
April 8, 2004
Publication date:
October 28, 2004
Applicants:
Neurocrine Biosciences, Inc., Stanford University Medical Center
Inventors:
Lawrence Steinman, Nicholas Ling, Paul J. Conlon, Amitabh Gaur
Abstract: Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any other amino acid. Pharmaceutical compositions of the peptide analogues are provided. In addition, the peptide analogues are administered to patients with multiple sclerosis.
Type:
Grant
Filed:
October 11, 2002
Date of Patent:
May 25, 2004
Assignees:
Neurocrine Biosciences, Inc., Stanford University Medical Center
Inventors:
Lawrence Steinman, Nicholas Ling, Paul J. Conlon, Amitabh Gaur
Abstract: Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any other amino acid. Pharmaceutical compositions of the peptide analogues are provided. In addition, the peptide analogues are administered to patients with multiple sclerosis.
Type:
Grant
Filed:
November 19, 2001
Date of Patent:
December 3, 2002
Assignees:
Stanford University Medical Center, Neurocrine Biosciences, Inc.
Inventors:
Lawrence Steinman, Nicholas Ling, Paul J. Conlon, Amitabh Gaur
Abstract: Peptide analogues of human myelin basic protein containing residues 87-99 are provided. Residue 91 of the peptide analogues is altered from the L-lysine residue found in the native protein to any other amino acid. Pharmaceutical compositions of the peptide analogues are provided. In addition, the peptide analogues are administered to patients with multiple sclerosis.
Type:
Grant
Filed:
October 20, 1997
Date of Patent:
April 9, 2002
Assignees:
Stanford University Medical Center, Neurocrine Biosciences, Inc.
Inventors:
Lawrence Steinman, Nicholas Ling, Paul J. Conlon, Amitabh Gaur