Patents Assigned to Stark Labs
  • SENESCENT CELL-ASSOCIATED ANTIGEN-BINDING DOMAINS, ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS COMPRISING THE SAME, AND USES THEREOF
    Publication number: 20220193130
    Abstract: The invention relates to DPP4-binding domains, as well as antibodies and chimeric antigen receptors (CAR) comprising the same. Also disclosed are methods for treating, preventing or alleviating senescence-related diseases or disorders, or for depleting and/or killing senescent cells.
    Type: Application
    Filed: September 25, 2020
    Publication date: June 23, 2022
    Applicant: Stark Labs
    Inventors: Müge OGRUNC, Thierry MATHIEU
  • CHIMERIC ANTIGEN RECEPTORS AGAINST SENESCENT CELLS AND USES THEREOF
    Publication number: 20210093665
    Abstract: The invention relates to a chimeric antigen receptor (CAR) comprising directed to at least one senescent cell-associated antigen, preferably to DEP1 and/or DPP4; including bispecific CAR, bispecific antibodies, and isolated immune cell population expressing the same. It also relates to uses and methods for treating, preventing or alleviating senescence-related diseases or disorders, or for depleting and/or killing senescent cells.
    Type: Application
    Filed: September 27, 2019
    Publication date: April 1, 2021
    Applicant: Stark Labs
    Inventors: Müge Ogrunc, Thierry Mathieu