Patents Assigned to Starks Associates, Inc.
  • Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof
    Patent number: 10738047
    Abstract: Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: August 11, 2020
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH, STARKS ASSOCIATES INC.
    Inventors: James Halpern Doroshow, Prabhakar Risbood, Jiamo Lu, Krishnendu Roy, Charles T. Kane, Jr., Md Tafazzal Hossain
  • Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof
    Patent number: 10131659
    Abstract: Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: November 20, 2018
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, STARKS ASSOCIATES INC.
    Inventors: James Halpern Doroshow, Prabhakar Risbood, Jiamo Lu, Krishnendu Roy, Charles T. Kane, Jr., Md Tafazzal Hossain
  • Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
    Patent number: 7834005
    Abstract: Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: November 16, 2010
    Assignees: The United States of America as represented by the Department of Health and Human Services, Starks Associates, Inc., Midwest Research Institute, Spirogen, Ltd.
    Inventors: Paul S. Liu, B. Rao Vishnuvajjala, Kenneth M. Snader, David E. Thurston, Philip W. Howard, Luke Y. Hsiao, Gregory Turner
  • PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND METHODS RELATED THERETO
    Publication number: 20090149449
    Abstract: Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.
    Type: Application
    Filed: February 13, 2009
    Publication date: June 11, 2009
    Applicants: The United States of America, as represented by the Secretary, Dept. of Health and Human Service, Starks Associates, Inc., Midwest Research Institute, Spirogen, Ltd.
    Inventors: Paul S. Liu, B. Rao Vishnuvajjala, Kenneth M. Snader, David E. Thurston, Philip W. Howard, Luke Y. Hsiao, Gregory Turner
  • Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
    Patent number: 7511032
    Abstract: Disclosed are compounds of Formula (I) wherein X, Y, Ri-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: March 31, 2009
    Assignees: The United States of America as represented by the Secretary, Department of Health and Human Services, Starks Associates, Inc., Midwest Research Institute, Spirogen, Ltd.
    Inventors: Paul S Liu, B. Rao Vishnuvajjala, Kenneth M Snader, David E Thurston, Philip W Howard, Luke Y Hsiao, Gregory Turner
  • Brefeldin A derivatives and their utility in the treatment of cancer
    Patent number: 5696154
    Abstract: Provided are brefeldin A derivatives of the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 is H and the other of R.sub.1 and R.sub.2 is a substituent group having 1 to 12 carbon atoms containing a basic nitrogen atom or a quaternary ammonium group, or a salt thereof. These derivatives exhibit good antitumor activity, and are administrable to human patients without the problems associated with brefeldin A.
    Type: Grant
    Filed: June 29, 1994
    Date of Patent: December 9, 1997
    Assignees: The United States of America as represented by the Department of Health and Human Services, Starks Associates, Inc.
    Inventors: Louis Malspeis, B. Rao Vishnuvajjala, Jeffrey G. Supko, Charles Theodore Kane, Jr.
  • N-(phosphonacetyl)-L-aspartic acid salts with piperazine, cyclohexylamine and calcium
    Patent number: 4348522
    Abstract: N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed. These methods include preparation of certain PALA compounds such as PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA.
    Type: Grant
    Filed: May 8, 1981
    Date of Patent: September 7, 1982
    Assignee: Starks Associates, Inc.
    Inventors: Robert J. Schultz, Fred W. Starks
  • N-(Phosphonoacetyl)-L-aspartic acid compounds
    Patent number: 4267126
    Abstract: N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed. These methods include preparation of certain PALA compounds such as PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA.
    Type: Grant
    Filed: January 23, 1980
    Date of Patent: May 12, 1981
    Assignee: Starks Associates, Inc.
    Inventors: Robert J. Schultz, Fred W. Starks
  • N-(Phosphonoacetyl)-L-aspartic acid compounds and methods for their preparation
    Patent number: 4215070
    Abstract: N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed. These methods include preparation of certain PALA compounds such as PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA.
    Type: Grant
    Filed: October 25, 1978
    Date of Patent: July 29, 1980
    Assignee: Starks Associates, Inc.
    Inventors: Robert J. Schultz, Fred W. Starks