Abstract: A pull rod bag with telescopic wheels (1) and a wheel telescoping operation mechanism, the wheel telescoping operation mechanism comprising: two pushing parts (9), the front end of each pushing part (9) can be connected with the rotating shaft (7) of a corresponding telescopic wheel (1); a transmission unit, comprising a transmission rod (8), two ends of the transmission rod (8) are connected with the rear end of a corresponding pushing part (9), respectively, such that the rotating shaft (7) of the corresponding telescopic wheel (1) can be driven to move back and forth in a mounting groove (45) when the transmission rod (8) moves up and down; and two locking parts (3), each locking part (3) can cooperate with a corresponding pushing part (9) so that the rotating shaft (7) of the telescopic wheel (1) connected with the corresponding pushing part (9) is locked in a folded state or an unfolded state.