Patents Assigned to State Institute
  • Publication number: 20200061595
    Abstract: Disclosed are passive NOx adsorbers and methods for synthesizing the same. Small-pore zeolitic materials with practical loadings of transition metals atomically dispersed in the micropores are described herein. Also demonstrated are simple and scalable synthesis routes to high loadings of atomically dispersed transition metals in the micropores of a small-pore zeolite.
    Type: Application
    Filed: August 21, 2019
    Publication date: February 27, 2020
    Applicants: BATTELLE MEMORIAL INSTITUTE, WASHINGTON STATE UNIVERSITY
    Inventors: Konstantin Khivantsev, Janos Szanyi, Nicholas R. Jaegers, Libor Kovarik, Feng Gao, Yong Wang
  • Publication number: 20200061185
    Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.
    Type: Application
    Filed: October 25, 2017
    Publication date: February 27, 2020
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The Scripps Research Institute, Trustees of Dartmouth College
    Inventors: Barney Graham, Jason McLellan, Andrew Ward, Robert Kirchdoerfer, Christopher Cottrell, Michael Gordon Joyce, Masaru Kanekiyo, Nianshuang Wang, Jesper Pallesen, Hadi Yassine, Hannah Turner, Kizzmekia Corbett
  • Patent number: 10465165
    Abstract: The present invention provides a multifunctional 2-D and 3-D matrix for propagation of stem cells. In particular, a chitosan-based biomaterial scaffold is engineered to promote CNS regeneration from primitive neural precursors by stabilizing a recombinant protein, fibroblast growth factor to preserve the cardinal properties of stem cells. The matrix, is further modified by the addition of either the extracellular matrix protein fibronectin or the small peptide RGD or IKVAV. A method to manufacture an injectable multifunctional microsphere scaffold is also disclosed that is suitable as a vehicle for cell transplantation to repair traumatic brain injuries.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: November 5, 2019
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, NEW JERSEY INSTITUTE OF TECHNOLOGY
    Inventors: Cheul Cho, Steven Levison, Nolan Skop, Frances Calderon, Chirag Gandhi
  • Patent number: 10452143
    Abstract: A device and method is described for electronic human prosthetics, and specifically a skull- and/or spine implantable bi-directional neural-communication/brain-machine interface (BBMI) device where the input, output and on-board computing are combined into a single unit to form a compact neuro-prosthetics device. This invention is also directed to a fully implantable wireless spinal electronic recording and stimulation system using the BBMI in a human. The bi-directional devices (BBMIs) communicate with other bi-directional brain-machine interface devices (BBMI) and/or with external controllers wirelessly. The compact implantable stimulator has ultrasonic secondary battery charging system. One or more BBMI can be wirelessly connected so that a closed loop of BBMIs, or a BBMI and an external controller, can wirelessly send trigger pulses to this fully implanted stimulator over the spinal cord.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: October 22, 2019
    Assignees: San Diego State University Research Foundation, Electronics and Telecommunication Research Institute
    Inventors: Kee S. Moon, Yusuf Ozturk, Sung Q. Lee, Woosub Youm, Gunn Hwang
  • Publication number: 20190262275
    Abstract: Materials and methods are described for forming self-assembled peptoid structures that are extremely stable, crystalline, free-standing and self-repairing are described. Based on the peptoid design, peptoid membranes in a 2D arrangement were able to roll into single-walled nanotubes with tunable sizes, diameters, thicknesses and stiffnesses as well as tailorable functions result. Crystalline nanomaterials made through this facile solution crystallization and anisotropic formation process are highly tailorable and exhibit a number of properties advantageous for applications such as water decontamination, cellular adhesion, imaging, surface coating, biosensing, energy conversion, biocatalysis or other applications.
    Type: Application
    Filed: May 8, 2019
    Publication date: August 29, 2019
    Applicants: BATTELLE MEMORIAL INSTITUTE, WASHINGTON STATE UNIVERSITY
    Inventors: Chunlong Chen, Mingming Wang, Teng-Yue Jian, Haibao Jin, Yuehe Lin, Yang Song, Dan Du
  • Patent number: 10112901
    Abstract: Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate intermediate 4 comprises: reacting a compound 3 with a C1-C3 alkyl alcohol solution of methylamine in an organic solvent, wherein, X=chlorine, bromine, or iodine. Also disclosed are an intermediate compound 3 and a preparation method thereof. The method for preparing a dabigatran etexilate intermediate of the present invention has the advantages of simple process, easy operation, high yield, and easy purification, thus being suitable for industrial production.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: October 30, 2018
    Assignees: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRY, CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
    Inventors: Yajun Guo, Hanbin Shan, Xueyan Zhu, Zhedong Yuan, Xiong Yu, Meng Guo, Mingtong Hu, Duzheng Wang, Yu Huang
  • Patent number: 9650403
    Abstract: Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: May 16, 2017
    Assignees: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRY
    Inventors: Baoquan Zhu, Yongzhi Shu, Jun Lin, Haifeng Hu, Quanhai Liu, Bin Zhou
  • Publication number: 20160194345
    Abstract: Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity.
    Type: Application
    Filed: March 19, 2014
    Publication date: July 7, 2016
    Applicants: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CHINA STATE INSTITUTE OF PHARMACEUTICAL INDUSTRY
    Inventors: Baoquan ZHU, Yongzhi SHU, Jun LIN, Haifeng HU, Quanhai LIU, Bin ZHOU
  • Publication number: 20140128463
    Abstract: Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.
    Type: Application
    Filed: June 25, 2012
    Publication date: May 8, 2014
    Applicants: China State Institute of Pharmaceutic Industry, Shanghai Institute of Pharmaceutical Industry
    Inventors: Zhenpeng Yu, Gouping Wang, Zhen Zhang, Minyu Liu, Xiaoling Huang, Ying Liu, Lin Xiao, Li Cai, Xuejun Wu, Yifang Deng, Mianli Pan, Renhai Chen, Shenrong Tang, Quanhai Liu
  • Patent number: 7927566
    Abstract: The present invention relates to a treatment of high-level waste of radiochemical production containing radionuclides and macro-admixtures including sodium. The method of extraction of radionuclides by processing acidic aqueous waste solutions by extractants containing macrocyclic compounds selected from the group of crown ethers having aromatic fragments containing alkyl and/or hydroxyalkyl substituents of a linear and/or branched structure, and/or cyclohexane fragments containing alkyl and/or hydroxyalkyl substituents of a linear and/or branched structure, and/or fragments of —O—CHR—CH2O—, where R is the normal or branched alkyl or hydroxyalkyl in organic solvents containing polyfluorinated telomeric alcohol 1,1,7-trihydrododecafluoroheptanol-1 having the formula H(CF2CF2)nCH2OH, where n=3, and a mixture of polyoxyethylene glycol ethers of synthetic primary higher aliphatic alcohols of a fraction C12-C14 of a general formula CnH2n+1O(C2H4O)mH, where n=12-14, m=2 is proposed.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: April 19, 2011
    Assignees: Designing-Contructing and Industrial-Inculcating Enterprise “Daymos Ltd.”, Federal State Institute “Federal Agency for Legal Protection of Military Special and Dual Use, Intellectual Activity Results” under Ministry of Justice of the Russian Federation (FSI “FALPIAR”)
    Inventors: Jury Vasilievich Glagolenko, Mikhail Vasilievich Logunov, Igor Vitalievich Mamakin, Vladimir Mikhailovich Polosin, Sergey Ivanovich Rovny, Vadim Alexandrovich Starchenko, Jury Pavlovich Shishelov, Nikolay Gennadievich Yakovlev
  • Publication number: 20010017260
    Abstract: An apparatus for electrolytic production of magnesium includes a plurality of upright anode elements interspread with a plurality of cathode elements situated within at least one electrolysis compartment. At least one section, defined between two adjacent anodes and having an elongated loading inlet, is provided for receiving and melting of a substantially solid raw material. A gas discharging outlet is formed for discharging of chlorine gas developed at the plurality of anodes. A baffle is supported by the receiving anodes in the vicinity of the gas discharging outlet. The baffle prevents direct flow of a mixture of chlorine gas and fine dust particles resulted from loading of the solid raw material between the section and gas discharging outlet.
    Type: Application
    Filed: December 19, 2000
    Publication date: August 30, 2001
    Applicant: State Institute
    Inventors: Igor V. Zabelin, Georgy M. Shehovtsov, Vladimir N. Deviatkin, Irina L. Sikorskaya, Alexander M. Tatakin, Tatiana V. Zabelina