Patents Assigned to State of Israel
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Patent number: 11951138Abstract: A method of mimicking a phenotype of a first ruminating animal in a second ruminating animal is disclosed. The method comprises administering to the second ruminating animal a microbial composition comprising a plurality of microbes having a signature which is statistically significantly similar to the microbial signature of a rumen microbiome of the first ruminating animal, wherein the first and the second ruminating animal are of identical species, thereby mimicking the phenotype of the first ruminating animal in the second ruminating animal.Type: GrantFiled: March 13, 2014Date of Patent: April 9, 2024Assignee: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)Inventors: Itzhak Mizrahi, Elie Jami
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Patent number: 11939620Abstract: A method of determining the feed efficiency and methane production of a ruminating animal comprising analyzing the number and/or diversity of a bacterial taxon of a microbiome of the animal or of a gene content of said microbiome, wherein a number and/or diversity of said taxon below a predetermined level is indicative of an animal having a high feed efficiency and low methane production, or a number of genes below a predetermined level is indicative of an animal having a high feed efficiency and low methane production.Type: GrantFiled: February 9, 2021Date of Patent: March 26, 2024Assignee: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)Inventor: Itzhak Mizrahi
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Patent number: 11931890Abstract: A human-robot system and method for performing an agricultural task, the system including: a robotic manipulator with an agricultural tool coupled to an end effector thereof; an imaging device adapted to capture imagery of a target, the imaging device mechanically coupled to the end effector; a laser distance sensor adapted to measure a distance between the manipulator and the target, the laser distance sensor mechanically coupled to the end effector and collocated with the imaging device; and a control unit including: a processing unit, a monitor and a human-machine interface (HMI), wherein the processing unit is configured to display the imagery on the monitor and to receive markings from the HMI and calculate a trajectory for the manipulator to perform the agricultural task with the tool.Type: GrantFiled: October 12, 2020Date of Patent: March 19, 2024Assignee: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI INSTITUTE)Inventors: Avital Bechar, Victor Bloch, Roee Finkelshtain
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Publication number: 20240057617Abstract: A preparation comprising gamma-necrodyl isobutyrate and an agriculturally acceptable carrier is disclosed for the monitoring and control of mealybugs. Methods of synthesizing the preparation and other mealybug pheromones that feature a necrodane structure are also disclosed.Type: ApplicationFiled: October 4, 2019Publication date: February 22, 2024Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Anat ZADA BYERS, Roy KASPI, Sara STEINER, Daniela FEFER
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Publication number: 20240052304Abstract: The present disclosure relates to deoxyribonucleic acid (DNA) editing agents, and their use in preparing DNA-edited cells and birds. The present disclosure further relates to gene-edited or genetically modified avians and gene-edited or genetically modified avian primordial germ cells (PGCs) for producing gene-edited or genetically modified avians (birds) that can serve as surrogate hosts for donor PGCs. The present disclosure further relates to methods for producing avian strains that can produce viable embryos and offspring, in both sexes, and for their subsequent use as surrogate hosts for donor PGCs.Type: ApplicationFiled: December 30, 2021Publication date: February 15, 2024Applicant: THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCHInventors: Yuval CINNAMON, Enbal BEN-TAL COHEN
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Publication number: 20240050491Abstract: A method of generating an antimicrobial agent is disclosed. The method comprises: (a) culturing Bacillus cells in a medium under conditions effective to allow secretion of at least one antimicrobial agent into the medium; and (b) purifying the at least one antimicrobial agent from the medium to generate a purified preparation comprising the at least one antimicrobial agent. Uses of the antimicrobial agents secreted from the Bacillus cells are also disclosed.Type: ApplicationFiled: September 14, 2023Publication date: February 15, 2024Applicant: The state of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Moshe SHEMESH, Yulia KROUPITSKI, Shlomo SELA
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Publication number: 20240041902Abstract: Compositions capable of reducing viability, initiating apoptosis, inducing cell cycle arrest and/or reducing migration of urothelial carcinoma cells and methods of use thereof are provided. The compositions and uses thereof comprise cannabinoids.Type: ApplicationFiled: December 8, 2021Publication date: February 8, 2024Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Hinanit KOLTAI, Omer ANIS
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Publication number: 20230413790Abstract: A fish of a tilapia genus comprising a loss-of-function mutation in a slc45a2 gene, wherein the mutation is in a homozygous form, and wherein the loss-of-function mutation results in an albino-red phenotype of the fish is disclosed. Methods of generating the fish are also disclosed.Type: ApplicationFiled: May 15, 2023Publication date: December 28, 2023Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Jakob BIRAN, Avner CNAANI, Adi SEGEV, Tatiana SLOSMAN
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Patent number: 11839195Abstract: A tomato plant exhibiting a facultative parthenocarpy is provided. The plant comprises a loss-of-function mutation in a SlAGL6 gene and alternatively or additionally characterized by an average fruit weight/plant at least about the same as that of a non-parthenocarpic tomato of the same genetic background under fertilization permissive conditions of the non-parthenocarpic tomato. Also provided are methods of producing such plants and processed products produced from same.Type: GrantFiled: January 19, 2017Date of Patent: December 12, 2023Assignee: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)Inventors: Rivka Barg, Yehiam Salts, Chen Klap, Itzhak Arazi, Ester Yeshayahou, Anthony Bolger, Sara Shabtai
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Patent number: 11833131Abstract: A method of treating an inflammatory disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), wherein the fraction comprises cannabis derived active ingredients other than the THCA.Type: GrantFiled: March 5, 2018Date of Patent: December 5, 2023Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research, Mor Research Applications Ltd.Inventors: Hinanit Koltai, Yoram Kapulnik, Moran Mazuz, Timna Naftali
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Patent number: 11827892Abstract: A polynucleotide comprising a nucleic acid sequence encoding an expression product of interest under a transcriptional control of a heterologous cis-acting regulatory element comprising a nucleic acid sequence at least 85% identical to SEQ ID NO: 2 (CsUbiquitin10), 4 (CsPs2), 6 (CsActin), 8 (CsTubulin), 10 (Cs EIF), 28 (metallothionein 2A), 30 (Catalase), 32 (Asparagine synthetase), 34 (60S ribosomal protein L3), 38 (40S ribosomal protein S3a), 40 (Phi-1 protein) or 44 (Receptor for activated protein kinase C) is provided. Also provided are nucleic acid constructs and cells comprising same.Type: GrantFiled: June 6, 2019Date of Patent: November 28, 2023Assignee: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)Inventors: Moshe Arie Flaishman, Reut Cohen Peer, Oded Cohen, Samuel Bocobza
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Patent number: 11812746Abstract: A method of controlling a fungus infection in a plant susceptible to Botrytis infection is provided. The method comprising applying to the plant an effective amount of a phenylalanine or an analog thereof for controlling said fungus infection in the plant.Type: GrantFiled: August 28, 2017Date of Patent: November 14, 2023Assignee: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER)Inventors: Michal Oren-Shamir, Moran Oliva, Efraim Lewinsohn, Noam Alkan, Yigal Elad
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Patent number: 11793767Abstract: The invention relates to the use of effective amount of Pelargonium graveolens essential oil or extract or constituents thereof selected from a group consisting of: (S)(?)citronellol, linalool, menthone and isomenthone or any combination thereof, in the preparation of a medicament for treating a mammal suffering from or susceptible to a neurodegenerative condition which can be improved or prevented by inhibition of acetylcholinesterase (ACliE).Type: GrantFiled: February 20, 2020Date of Patent: October 24, 2023Assignee: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT AGRICULTURE RESEARCH ORGANIZATIONInventors: Anat Elmann, Uzi Ravid
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Publication number: 20230329170Abstract: A tomato plant or a part thereof is disclosed. The plant expresses a Tm-22 protein having an amino acid sequence which renders the plant resistant to tomato brown rugose fruit virus (ToBRFV). Methods of generating same are also disclosed. Products generated therefrom are described.Type: ApplicationFiled: May 2, 2023Publication date: October 19, 2023Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Ziv SPIEGELMAN, Hagit HAK, Ezra Joseph LOEB, Yifat SHERMAN
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Patent number: 11752125Abstract: The invention relates to 3,5,4?-trihydroxy-6,7,3?-trimethoxyflavone (TIF) and achillolid A in prevention or treatment of Alzheimer's disease as well as other neurodegenerative diseases such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), ischemia, immunodeficiency virus-1 (HTV-1)-associated dementia, Lewy body associated dementia, traumatic brain injury (TBI), glioma, epilepsy. Huntington's disease, multiple sclerosis, glaucoma and schizophrenia where neuroinflammation, oxidative stress, glutamate toxicity and amyloid beta toxicity are part of the pathophysiology.Type: GrantFiled: November 26, 2014Date of Patent: September 12, 2023Assignee: THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATIONInventors: Anat Elmann, Rivka Ofir, Yoel Kashman
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Publication number: 20230277564Abstract: Cannabinoidal compositions for the treatment of disease are provided. Accordingly, there is provided a method of treating a disease that can benefit from activating macrophages comprising administering to the subject a therapeutically effective amount of a composition comprising a cannabis derived fraction comprising phytocannabinoids, wherein said phytocannabinoids comprise at least 80% CBD and at least one of CBG and THCV. Also provided is a method of treating a cytokine storm comprising administering to the subject a therapeutically effective amount of a synthetic composition comprising phytocannabinoids, wherein said phytocannabinoids comprise at least 80% CBD and at least one of CBG and THCV.Type: ApplicationFiled: April 4, 2023Publication date: September 7, 2023Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Hinanit KOLTAI, Nurit SHALEV, Dvora NAMDAR, Guy MECHREZ
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Publication number: 20230263182Abstract: Described herein are a method of preparing a vegetable oil, comprising pressing a non-fruit tissue of a date palm offshoot, as well as a vegetable oil and a polysaccharide-containing fraction obtained by such a method. Further described herein is an oil comprising esters of fatty acids, wherein at least 10 weight percent of the fatty acids are linolelaidic acid, as well as compositions comprising a variety of ingredients, such as saccharides and amino acids, as characterized herein, and a method of isolating dihydrouracil from an oil and/or composition described herein. Further described is a method of preparing a vegetable oil, comprising pressing date kernel tissue.Type: ApplicationFiled: September 1, 2021Publication date: August 24, 2023Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Hinanit KOLTAI, Dvora NAMDAR
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Publication number: 20230226538Abstract: A system configured to determine the load in a liquid sample of predetermined antigens is provided. The system comprises a measurement chamber configured for receipt therein of the liquid sample, a sensor circuit, and an analysis unit. The sensor circuit comprises a plurality of working electrodes, each comprising antibodies on its surface associated with one of the predetermined antigens, at least one reference electrode, and at least one counter electrode. Proximal ends of the electrodes are disposed on a reading zone of the sensor circuit, the reading zone being disposed within the measurement chamber. The analysis unit is configured to facilitate the determination of the load of each of the antigens by measuring electrical properties of the electrodes.Type: ApplicationFiled: April 7, 2021Publication date: July 20, 2023Applicant: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATIONInventors: Sefi VERNICK, Roy POSMANIK
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Publication number: 20230212696Abstract: The present disclosure provides method and compositions for predicting and increasing the survival of fish after stress.Type: ApplicationFiled: August 25, 2020Publication date: July 6, 2023Applicants: The State of Israel , Ministry of Agriculture & Rural Development, Agricultural Research Organizatio, ISRAEL OCEANOGRAPHIC AND LIMNOLOGICAL RESEARCH, LTD., The Dead-Sea and Arava Science Center (DSASC)Inventors: Galit SHARON, Ashraf Mohammad Fahmi Rashad AL ASHHAB
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Patent number: 11690358Abstract: The present invention provides a system and method for recognizing and segregating chicks by sex according to their feathers pattern. The system and method are based on the instinctive reaction of chicks to spread their wings in order to maintain stability in response to instantaneous disorientation, for example, due to a sudden change in spatial movement. The present invention further features a weighing system and a system for detecting external body defects of chicks for assessing chicks' health.Type: GrantFiled: December 6, 2020Date of Patent: July 4, 2023Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agriculture Research Organization, ESHET EILON INDUSTRIES LTD.Inventors: Amos Mizrach, Victor Alchanatis, Nachshon Shamir, Lavi Rosenfeld, Clara Shenderey, Asher Levi, Viacheslav Ostrovsky, Menashe Tamir, Reuven Shadmi, Avishay Tamir