Abstract: Disclosed are Mannich base N-oxides of drugs containing acidic N—H groups. Pharmaceutical compositions comprising a therapeutically effective amount of Mannich base N-oxides, or a N-oxide rearrangement product, pharmaceutically acceptable salt or prodrug thereof, are also disclosed. Further, disclosed are methods of using the compounds, alone or in combination with one or more other active agents or treatments.
Type:
Application
Filed:
September 21, 2009
Publication date:
January 21, 2010
Applicant:
State of Oregon Acting By and Through The Oregon State Board of Higher Education On Behalf of The U
Inventors:
John F.W. Keana, Paul Westberg, John Curd, Alshad S. Lalani