Abstract: The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
Type:
Grant
Filed:
August 20, 2014
Date of Patent:
January 1, 2019
Assignees:
Allvivio Vascular, Inc., State of Oregon acting by and through the State Board of Higher Ed. on Behalf of Oregon State Univ.
Inventors:
Jennifer A. Neff, Joseph McGuire, Pranav Joshi
Abstract: The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
Type:
Grant
Filed:
May 15, 2012
Date of Patent:
December 3, 2013
Assignees:
Allvivo Vascular, Inc., The State of Oregon Acting by & through the State Board of Higher Ed. on Behalf of Oregon State Univ.
Inventors:
Jennifer A. Neff, Joseph McGuire, Pranav R. Joshi
Abstract: The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
Type:
Application
Filed:
May 15, 2012
Publication date:
October 4, 2012
Applicants:
The State of Oregon Acting by & through the State Board of Higher Ed. on Behalf of Oregon State Univ, ALLVIVO VASCULAR, INC.
Inventors:
Jennifer A. Neff, Joseph McGuire, Pranav R. Joshi
Abstract: The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.
Type:
Grant
Filed:
July 11, 2008
Date of Patent:
May 15, 2012
Assignees:
Allvivo Vascular, Inc., The State of Oregon Acting by and through the State Board of Higher Ed. on Behalf of Oregon State Univ.
Inventors:
Jennifer A. Neff, Joseph McGuire, Pranav R. Joshi