Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.
Type:
Grant
Filed:
September 24, 2001
Date of Patent:
December 17, 2002
Assignees:
The Regents of the University of California, State of Oregon c/o Oregon State University, GlaxoSmithKline
Inventors:
Robert S. Jacobs, Lisa A. Marshall, William H. Gerwick, Christopher Stevenson