Abstract: N,N-disubstituted-guanidines, e.g., of the formula ##STR1## wherein R and R' are substituted or unsubstituted hydrocarbon groups. Methods are provided for the treatment of psychosis and hypertension by administering an effective amount of an N,N'-disubstituted guanidine which, preferably, has a high affinity for the sigma receptor.
Type:
Grant
Filed:
February 23, 1993
Date of Patent:
December 26, 1995
Assignee:
State of Oregon, Oregon Health Sciences University of Oregon
Abstract: The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adrenocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTH.sup.R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH.sup.R receptor gene. The invention specifically provides human and bovine ACTH.sup.R genes.
Type:
Grant
Filed:
April 10, 1992
Date of Patent:
January 18, 1994
Assignee:
State of Oregon, Oregon Health Sciences University
Abstract: A DNA probe p144-D6 is homologous to at least a portion of a hypervariable DNA region located on chromosome 17(17p13) in the human genome. The DNA region displays a restriction fragment length polymorphism when digested with certain restriction endonucleases. Unrelated invididuals often display unique fragment patterns on Southern blots probed with p144-D6. The probe can be used to produce a genetic "fingerprint" for establishing human identity, determining engraftment of bone marrow transplants, determining parentage, and otherwise mapping genes.
Type:
Grant
Filed:
August 30, 1988
Date of Patent:
December 31, 1991
Assignee:
State of Oregon . . . Oregon Health Sciences University