Patents Assigned to State University
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Publication number: 20180318406Abstract: A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat fungal infections. The novel vaccine can provide protective immunity, even for immunocompromised individuals such as HIV patients having reduced levels of CD4+ T cells.Type: ApplicationFiled: July 13, 2018Publication date: November 8, 2018Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical CollegeInventors: Jay K. Kolls, Michael Zheng, Karen Norris, Heather Kling
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Patent number: 10120980Abstract: Improved pulmonary embolism (PE) detection may be obtained through computer aided-diagnosis. In particular, PE detection may be accomplished through patient-level diagnosis, embolus-level detection, or a combination of the two. Patient-level diagnosis operates to quickly exclude non-PE patients and dispatch PE-patients to treatment. Embolus-level detection operates to localize individual emboli to support personalized medicine via risk stratification. Multiple instance-based learning (MIBL) classification at the patient level explores the key observation that once any TP candidate of a patient is classified as positive, the patient is identified as PE positive. That is, MIBL focuses on correct classification of patients rather than individual candidates, to effectively and rapidly distinguish between PE patients and non-PE patients.Type: GrantFiled: January 27, 2015Date of Patent: November 6, 2018Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventor: Jianming Liang
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Patent number: 10119960Abstract: Systems and methods for performing cancer screening assays are disclosed. The disclosed systems and methods use a thin film comprising cross-linked polysiloxane. At least a portion of a biological sample to be assayed is contacted with the thin film, along with a cell culture media. After a subsequent incubation period, the thin film is visualized to detect a wrinkle pattern (or lack thereof). The presence of one or more wrinkles and/or a higher degree of wrinkling in the thin film indicates the presence of cancer cells in the biological sample. The disclosed systems and methods can be incorporated into improved assays and kits for cancer screening.Type: GrantFiled: June 9, 2015Date of Patent: November 6, 2018Assignees: Arizona Board of Regents on Behalf of Arizona State University, The Board of Trustees of the Leland Stanford Junior University, The U.S. Government represented by the Department of Veteran AffairsInventors: Junseok Chae, Jennie Appel, Joseph Liao
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Patent number: 10119029Abstract: The present invention is directed to a method of isolating fractions of anthocyanin molecules from anthocyanin-containing vegetable and fruit juices and extracts, or combinations thereof, at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts.Type: GrantFiled: February 7, 2017Date of Patent: November 6, 2018Assignees: Mars, Incorporated, The Ohio State UniversityInventors: Rebecca J. Robbins, J. Christopher Johnson, Thomas M. Collins, Neda Ahmadiani, M. Monica Giusti
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Patent number: 10119003Abstract: A method for making a surfactant-based monolithic column is provided. The method comprises providing a mixture comprising at least one surfactant monomer, at least one crosslinker, at least one initiator, and at least one porogen and polymerizing the mixture to form the surfactant-based monolithic column. The present disclosure also provides a surfactant-based monolithic column, a method for separating molecules, and a process for preparing a surfactant monomer.Type: GrantFiled: May 3, 2013Date of Patent: November 6, 2018Assignee: Georgia State University Research Foundation, Inc.Inventors: Shahab Ahmed Shamsi, Congying Gu, Jun He
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Patent number: 10117990Abstract: A microfluidic intravital window includes an intravital imaging window adapted for implantation adjacent target tissue of a live animal, and a microfluidic fluid source and delivery system physically integrated into the window for controlled delivery of fluids to target tissue via the window. The microfluidic fluid source and delivery system is self-contained and completely located within the intravital imaging window, and includes at least one preloaded fluid reservoir, at least one fluid port in fluidic communication with both the at least one preloaded fluid reservoir and the target tissue, and at least one light activated fluid flow control device situated between the at least one preloaded fluid reservoir and at least one fluid port, to facilitate simultaneous in vivo viewing and remotely controlled fluid delivery to the target tissue.Type: GrantFiled: December 7, 2016Date of Patent: November 6, 2018Assignees: The Research Foundation for the State University of New York, Albert Einstein College of Medicine, Inc.Inventors: James Castracane, Logan Butt, David Entenberg, Lauren Sfakis, John Condeelis
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Patent number: 10117629Abstract: Imaging techniques that may be used in applications such as differential phase contrast imaging are disclosed that include, for example, configuring a beam source and a beam detector such that a beam connects the two, positioning an object, a phase grating and an analyzer grating in the beam path, producing multiple data sets based on various analyzer grating positions, and conducting a regression analysis using a predetermined function having a set of fitting coefficients to establish those fitting coefficients. In those techniques, the fitting coefficients may be used to characterize a set of interference properties associated with the object.Type: GrantFiled: December 3, 2015Date of Patent: November 6, 2018Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Leslie G. Butler, Kyungmin Ham, Warren W. Johnson
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Patent number: 10119286Abstract: A wave propagation apparatus. The apparatus includes a container enclosing a base layer/liquid and an overlying layer/liquid separated from each other. Above the overlying layer is a driver sprocket and a driven sprocket, which rotate about their respective central shafts, which are fixed across a width of the container. A closed chain loop is disposed around the sprockets, with a plurality of paddles secured thereto at a spaced distance away from each other. The chain rotates about the sprockets as they rotate about the central shafts. The driver sprocket rotates via a motor, which is controlled by a controller and powered by a power source. The paddles travel through the overlying layer but not through the base layer, thus displacing the fluid in the overlying layer and causing a dragging wave to appear in the base layer, due to the surface friction between the base layer and the overlying layer.Type: GrantFiled: May 3, 2018Date of Patent: November 6, 2018Assignee: The Florida State University Research Foundation, Inc.Inventor: Philip Gleason
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Patent number: 10119197Abstract: A Dye Sensitized Photoelectrosynthesis Cell (DSPEC) splits water with visible light using a derivatized, core/shell nanostructured photoanode with the core having a high surface area conductive metal oxide film—such as nanoITO (indium tin oxide) or nanoATO (antimony tin oxide)—coated with a thin outer shell of, for example, TiO2 formed by Atomic Layer Deposition (ALD). A “chromophore-catalyst assembly” 1, [(PO3H2)2bpy)2Ru(4-Mebpy-4-bimpy)Ru(tpy)(OH2)]4+, which combines both light absorber and water oxidation catalyst in a single molecule, is attached to the TiO2 shell. Visible photolysis of the resulting core/shell/assembly structure with a Pt cathode results in water splitting into hydrogen and oxygen.Type: GrantFiled: September 8, 2014Date of Patent: November 6, 2018Assignees: The University of North Carolina at Chapel Hill, North Carolina State UniversityInventors: Leila Alibabaei, Matthew Kyle Brennaman, Michael Norris, Gregory N. Parsons, Thomas J. Meyer
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Patent number: 10119147Abstract: The present invention relates to Brassica plants comprising mutant phosphatidylcholine:diacylglycerol cholinephosphotransferase encoding (ROD1) genes, ROD1 nucleic acid sequences and proteins, as well as methods for generating and identifying said plants and alleles, which can be used to plants with increased levels of C18:1 in the seeds.Type: GrantFiled: July 4, 2013Date of Patent: November 6, 2018Assignees: Washington State University, Bayer CropScience NVInventors: Peter Denolf, Shuangyi Bai, John Browse
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Publication number: 20180315473Abstract: A static random access memory (SRAM) bit cell and a related SRAM array are provided. In one aspect, an SRAM cell is configured to perform an XNOR function on a first input value and a second input value. In another aspect, a number of the SRAM cells can be employed to form an SRAM array for supporting deep neural network and machine learning applications. The SRAM cell is coupled to a word line(s) and an inverted word line(s) that collectively define the first input value. The SRAM cell causes a voltage and/or current difference between a bit line(s) and a complementary bit line(s) coupled to the SRAM cell. By customizing the SRAM cell to enable the XNOR function and forming a binary neural network based on the SRAM array, it is possible to effectively implement computing-in-memory (CIM) for deep neural network and machine learning applications.Type: ApplicationFiled: April 24, 2018Publication date: November 1, 2018Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Shimeng Yu, Rui Liu
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Publication number: 20180311657Abstract: Catalysts useful in transforming biomass to bio-oil are disclosed, as are methods for making such catalysts, and methods of transforming biomass to bio-oil. The catalysts are especially useful for, but are not limited to, microwave- and induction-heating based pyrolysis of biomass, solid waste, and other carbon containing materials into bio-oil. The catalysts can also be used for upgrading the bio-oil to enhance fuel quality.Type: ApplicationFiled: June 21, 2018Publication date: November 1, 2018Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Dorin Boldor, Daniel Hayes
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Publication number: 20180311599Abstract: Stabilized air filters formed from mats of crosslinked protein-containing fibers are provided. The fibers are formed into a mat with pores that allow air to pass through while physically filtering particulate matter. The protein in the protein-containing fibers also serves to chemically filter polluted air passed through the filter. Specifically, chemical functional groups from the many amino acids that comprise the protein of the protein-containing nanowire react with certain chemical pollutants (e.g., carbon monoxide and formaldehyde) in order to capture or otherwise neutralize the pollutant. Accordingly, the single fiber mat performs two filtering functions. Methods for making the air filters from crosslinked protein-containing nanofibers are also provided.Type: ApplicationFiled: May 1, 2018Publication date: November 1, 2018Applicant: Washington State UniversityInventors: Wei-Hong Zhong, Hamid Souzandeh, Yu Wang
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Publication number: 20180312823Abstract: The invention relates to amino acid sequence variants of a lipase with improved activity for catalyzing synthesis reactions and methods of preparing the variants. The methods include predicting amino acid sites for change based on computational models of the protein structure in non-aqueous conditions, and expressing the protein in a prokaryotic host for subsequent purification and use. The enzyme sequence variants described have a three to nine-fold improvement in synthesis activity over the parent protein sequence.Type: ApplicationFiled: July 9, 2018Publication date: November 1, 2018Applicants: Eastman Chemical Company, North Carolina State UniversityInventors: Stephanie Kay Clendennen, Yaroslava Georgievna Yingling, Hoshin Kim
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Patent number: 10112960Abstract: Methods for the selective borylation of arenes, including arenes substituted with an electron-withdrawing group (e.g., 1-chloro-3-fluoro-2-substituted benzenes) are provided. The methods can be used, in some embodiments, to efficiently and regioselectively prepare borylated arenes without the need for expensive cryogenic reaction conditions.Type: GrantFiled: September 5, 2014Date of Patent: October 30, 2018Assignees: Dow AgroSciences LLC, The Board of Regents of the Michigan State UniversityInventors: Milton R. Smith, Robert E. Maleczka, Hao Li, Chathurika R. K. Jayasundara, Jossian Oppenheimer, Dmitrijs Sabasovs
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Patent number: 10111855Abstract: Equol (7-hydroxy-3(4?hydroxyphenyl)-chroman), or metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5?-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes.Type: GrantFiled: January 3, 2018Date of Patent: October 30, 2018Assignees: Brigham Young University, Colorado State University Research FoundationInventors: Edwin Douglas Lephart, Trent D. Lund, Robert J. Handa
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Patent number: 10111448Abstract: The compositions, methods, and system of the invention provide increased nutrients and kidney size and reduced fat and risks of cardiovascular disease in animals by utilizing njangsa (Ricinodendron heudelotii) as a feed and oral supplement for the animals.Type: GrantFiled: August 13, 2016Date of Patent: October 30, 2018Assignee: Alcorn State UniversityInventors: Michael O. Ezekwe, Samuel A. Besong
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Patent number: 10116159Abstract: This invention presents a family of isolated BESS topologies with multiple functions, which are suitable for high voltage and high power DC grid application. A battery energy storage system (BESS) for direct current (DC) grid applications is provided, including an alternating current (AC) transformer having a primary side and a secondary side, at least one primary side arm coupled to the primary side of the AC transformer, the at least one primary side arm comprising a plurality of cascade connected voltage source converter sub-modules and a plurality of energy storage battery units and at least one secondary side arm coupled between the secondary side of the AC transformer and a DC grid voltage bus, the at least one secondary side arm comprising a plurality of cascade connected voltage source converter sub-modules. Modulation and control strategies for the various topologies are also provided.Type: GrantFiled: June 2, 2016Date of Patent: October 30, 2018Assignee: The Florida State University Research Foundation, Inc.Inventors: Hui Li, Rui Li, Yanjun Shi
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Patent number: 10112023Abstract: A device, system, and method for isolating a ventilator from one or more patients in which the delivery conditions of gas delivered to an isolation device from a ventilator may drive the delivery of breathing-gas delivered to one or more patients, the breathing-gas having the same or different delivery conditions. In one embodiment, an isolation device may have a housing and a movable partition. The movable partition may be joined to the housing, The movable partition may have a patient side on a first side of the partition and an actuating side on a second side of the partition. The isolation device may include an inlet pressure regulator on the actuating side and/or an exhaust pressure regulator on the patient side. These regulators may alter the delivery conditions (including, but not limited to, pressure and volume) of breathing-gas delivered to a patient.Type: GrantFiled: December 9, 2013Date of Patent: October 30, 2018Assignee: The Research Foundation for The State University of New YorkInventors: Bradley P. Fuhrman, Mark S. Dowhy
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Patent number: PP29803Abstract: ‘NCORNSP-020BWGWE’ is a compact, non-twining, upright variety producing many short shoots. It is distinguishable from other cultivars by its yellow green heart shaped leaves with dentate to serrate irregular projecting points (i.e. teeth) with a cordate-deltoid base; a compact habit and erect mounding plant architecture. The lime green, toothed leaves of this plant, short internodes, and the plant architecture are what makes ‘NCORNSP-020BWGWE’ unique amongst the current ornamental sweetpotatoes in the marketplace. ‘NCORNSP-020BWGWE’ also exhibits very good vigor and is very well branched. In greenhouse and field trials conducted since 2013, ‘NCORNSP-020BWGWE’ has been shown to be much less vigorous than Ipomoea batatas ‘Margarita’ and ‘Blackie’ and is suitable for use as a landscape or containerized plant. The production of flowers by ‘NCORNSP-020BWGWE’ is sporadic under short day conditions.Type: GrantFiled: November 4, 2016Date of Patent: November 6, 2018Assignee: North Carolina State UniversityInventors: George Craig Yencho, Meri K. Reeber, Kenneth Vincent Pecota
