Abstract: An encapsulated polymer stabilized cholesteric texture (EPSCT) light shutter is formed from a cholesteric liquid crystal and monomer that is encapsulated into micron sized, polymer-coated droplets by either an emulsification or phase separation process. The polymer-coated droplets are disposed between transparent electrodes, where they are irradiated by ultra-violet (UV) light to polymerize the monomer.
Abstract: Threshold gates and related circuitry are disclosed. In one embodiment, a threshold gate includes a threshold realization element and a magnetic tunnel junction (MTJ) element. The MTJ element is switchable from a first resistive state to a second resistive state. To realize a threshold function with the MTJ element, the threshold realization element is configured to switch the magnetic tunnel junction element from the first resistive state to the second resistive state in accordance with the threshold function. In this manner, the threshold gate may implement a threshold function that provides an output just like a complex Boolean function requiring several Boolean gates.
Type:
Grant
Filed:
May 28, 2013
Date of Patent:
April 5, 2016
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
Inventors:
Sarma Vrudhula, Nishant S. Nukala, Niranjan Kulkarni
Abstract: The use of the electride form of 12CaO-7Al2O3, or C12A7, as a low work function electron emitter in a hollow cathode discharge apparatus is described. No heater is required to initiate operation of the present cathode, as is necessary for traditional hollow cathode devices. Because C12A7 has a fully oxidized lattice structure, exposure to oxygen does not degrade the electride. The electride was surrounded by a graphite liner since it was found that the C12A7 electride converts to it's eutectic (CA+C3A) form when heated (through natural hollow cathode operation) in a metal tube.
Type:
Grant
Filed:
April 28, 2014
Date of Patent:
April 5, 2016
Assignee:
Colorado State University Research Foundation
Inventors:
Lauren P. Rand, John D. Williams, Rafael A. Martinez
Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
Type:
Grant
Filed:
November 12, 2013
Date of Patent:
April 5, 2016
Assignees:
BAXALTA INCORPORATED, BAXALTA GMBH, Research Foundation of the State University of New York, Brookhaven Science Associates, LLC
Inventors:
Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
Abstract: Compounds and uses of the compounds are provided. The compounds can be used as Fe(II) sequestering compounds. For example, these compounds can be used to sequester Fe(II) in cells, organs, vasculature, or tissues. Also, provided are compositions and methods of using the them for sequestering Fe(II) in an individual. The compounds can be used as MRI paraCEST contrast agents.
Type:
Grant
Filed:
May 11, 2012
Date of Patent:
April 5, 2016
Assignee:
The Research Foundation for The State University of New York
Abstract: Recombinant attenuated Y. pseudotuberculosis mutants have been created that show efficacy as oral vaccines against plague caused by Y. pestis and Yersinosis caused by both Y. enterocolitica and Y. pseudotuberculosis. Thus, live attenuated Y. pseudotuberculosis-based vaccines can be used to prevent Yersinosis in farm animals such as swine, cattle and sheep. The palatable baits containing live attenuated Y. pseudotuberculosis-based vaccines may be acceptable methods to control plague epidemics in wild animals. The methods disclosed can also be used to generate recombinant attenuated Y. entercolitica and Y. pestis vaccine strains.
Type:
Application
Filed:
September 10, 2015
Publication date:
March 31, 2016
Applicant:
Arizona Board of Regents on behalf of Arizona State University
Abstract: A hydraulic cell stretching device comprising a source of variable pressured hydraulic fluid hydraulically coupled to a flexing chamber. The flexing chamber has at least one cell well. The cell well has a membrane subjected to the variable pressured hydraulic fluid.
Type:
Application
Filed:
September 25, 2015
Publication date:
March 31, 2016
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Kevin John McCARTHY, Deborah Jane WASSENHOVE-McCARTHY
Abstract: Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.
Type:
Grant
Filed:
August 18, 2015
Date of Patent:
March 29, 2016
Assignee:
The Ohio State University Research Foundation
Abstract: Disclosure is provided for imidazole derivative compounds useful to inhibit the formation of biofilms and/or inhibit microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same.
Type:
Grant
Filed:
September 24, 2013
Date of Patent:
March 29, 2016
Assignee:
North Carolina State University
Inventors:
Christian Melander, W. Steve McCall, Zhaoming Su, Roberta Melander
Abstract: An optical element includes at least two stacked birefringent layers having respective local optical axes that are rotated by respective twist angles over respective thicknesses of the at least two layers, and are aligned along respective interfaces between the at least two layers. The respective twist angles and/or the respective thicknesses are different. The at least two stacked birefringent layers may be liquid crystal polymer optical retarder layers. Related devices and fabrication methods are also discussed.
Type:
Grant
Filed:
October 5, 2012
Date of Patent:
March 29, 2016
Assignee:
North Carolina State University
Inventors:
Michael J. Escuti, Ravi K. Komanduri, Kristopher F. Lawler, Jr.
Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
Type:
Grant
Filed:
March 7, 2013
Date of Patent:
March 29, 2016
Assignees:
Arizona Board of Regents for and on behalf of Arizona State University, The Washington University
Inventors:
Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
Abstract: The present invention provides devices and associated methods to facilitate multiplexed staining on a slide. The use of multiplexed staining on a single slide allows for more accurate disease diagnosis while also conserving sample. A PDMS based cytology overlay was created that is capable of coupling on-chip morphological, cytochemical, and immunological staining. Morphological and cytochemical staining of blood smears, along with immunostaining of lymph node imprints, was carried out to demonstrate the application of this microfluidic cytology chip (?CC) device.
Type:
Grant
Filed:
March 8, 2012
Date of Patent:
March 29, 2016
Assignee:
Colorado State University Research Foundation
Inventors:
Charles Henry, Matthew Feirer, Meghan Mensack
Abstract: Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.
Type:
Grant
Filed:
November 1, 2007
Date of Patent:
March 29, 2016
Assignees:
Immport Therapeutics, Inc., Rutgers, The State University of New Jersey
Inventors:
Philip Felgner, David Huw Davies, Xiaowu Liang, Maria Laura Gennaro
Abstract: Several mutated strains of Scheffersomyces stipitis are generated by repetitive culturing of the parent strain on two types of concentrated hydrolyzates and with ethanol-challenged xylose-fed continuous culture. Isolates collected from various enriched populations are screened and ranked based on relative xylose uptake rate and ethanol yield. Ranking on hydrolyzates with and without nutritional supplementation is used to identify those isolates with best performance across diverse conditions.
Type:
Grant
Filed:
January 29, 2014
Date of Patent:
March 29, 2016
Assignees:
The United States of America, as represented by the Secretary of Agriculture, Board of Trustees of Michigan State University
Inventors:
Patricia J. Slininger, Stephanie R. Thompson, Venkatesh Balan, Leonardo Da Costa Sousa, Bruce Dale, Maureen A. Shea-Andersh, Bruce S. Dien
Abstract: ‘NCPX1’ is a new cultivar of hybrid flowering pear with a narrow fastigiated habit, red to purple flower buds opening with white flower petals and a high level of resistance to fire blight.
Abstract: Buddleja ‘Blue Chip Jr’ is a new and distinct variety of butterfly bush that has the following unique combination of desirable features that are outstanding in a new variety. ‘Blue Chip Jr’ has low vigor resulting in very dwarf stature. ‘Blue Chip Jr’ is asexually propagated using softwood or semi-hardwood cuttings. ‘Blue Chip Jr’ demonstrates a dense, spreading growth habit. ‘Blue Chip Jr’ is lacking male flower parts (anthers), resulting in male (pollen) sterility. ‘Blue Chip Jr’ produces female structures that are essentially sterile, resulting in lack of seed formation. ‘Blue Chip Jr’ has purple-violet flower color.