Abstract: Anti-angiogenic agents or polypeptides comprising an amino acid segment substantially similar to domain one of CD2 wherein the polypeptide has a ?-sheet formed by two segments. Methods of using such agents and polypeptide are also included.

Abstract: Compounds which are active against viruses have the following Formulas: wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR1, OR2, or SR3; R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, and C4-18 cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl; R2 is selected from the group consisting of C2-18 alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; and R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.

Abstract: The invention provides a method of treating a target area with an ultrasound wave pattern, including: providing an ultrasound apparatus having an ultrasound wave generator operatively attached to a plurality of transducers, coupled to an immersible support and configured to emit an ultrasound wave; immersing the apparatus into a water environment; positioning the apparatus proximate to a target area to treat at least one in situ organism; and emitting a pattern of ultrasound waves from the transducers, the pattern of ultrasound waves additive in effect and emitted onto the target area to threat an in situ underwater organism.

Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.

Abstract: The invention provides compounds of formula (I): wherein R1-R3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

Abstract: Described are helmets that include a shell that has a first layer, a second layer, and a third layer. The second layer is positioned between the first layer and the third layer. The second layer is less dense than the first layer and the third layer.

Abstract: Methods and apparatuses for speeding the softening of the cervix (cervical ripening) by way of application of ultrasound energy. A vaginal transducer may be used to emit pulse-modulated ultrasound energy directed to the cervix. Focused ultrasound energy may be applied trans-abdominally and directed at the cervix. Ultrasound energy is widely used in medical applications such as diagnostic imaging, therapeutic heating and noninvasive surgery.

Abstract: The present invention describes a non-aqueous organic solution for Electrophoretic Deposition (EPD) of nanoparticles onto thin films, including method of using said non-aqueous organic solution and EPD to produce films containing such nanoparticles for use in LED devices, Li ion batteries, as solar absorbers, and as thin film transistors.

Abstract: Activity-dependent gene pairs as therapeutic targets and methods and devices to identify the same are provided. The methods and devices allow transcriptome-wide analysis of regulatory long non-coding RNAs (IncRNAs), matched with differentially expressed protein-coding genes (mRNAs) and/or with other IncRNAs. The described methods and devices allow analysis of these activity-dependent gene pairs as therapeutic targets in a number of clinical conditions associated with altered electrical brain activity, including epilepsy.

Abstract: A method for isolating and processing bone marrow derived stem cells, including the steps of: (a) collecting a biological sample containing adherent bone marrow stem cells in a receptacle with interior walls coated with a cell-adherent substrate; (b) incubating the bone marrow cells on the adherent substrate so that a layer of adherent bone marrow stem cells adheres to the substrate; (c) washing any non-adherent cells from the substrate; and (d) collecting the bone marrow stem cell layer. Isolation kits and use of bone marrow cells harvested for cell therapies are also described.

Abstract: A gas turbine engine comprises a fan, and a fan drive turbine rotor. The fan drive turbine drives the fan through a gear reduction. The gear reduction includes at least two double helical gears in meshed engagement. Each of the at least two double helical gears are disposed to rotate about respective axes, and each have a first plurality of gear teeth axially spaced from a second plurality of gear teeth by a spacer. Each of the first plurality of gear teeth has a first end facing the spacer and each of the second plurality of gear teeth has a first end facing the spacer. Each first end of the first plurality of gear teeth is circumferentially offset from each first end of the second plurality of gear teeth.

Abstract: The invention is directed to compositions, e.g., cell-based and multiplexed platforms, to screen for small molecule drugs that inhibit enzymes such as proteases, e.g., viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., viral proteases such as HIV proteases. In alternative embodiments, the invention provides cell-based platforms or assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelope protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products. In one embodiment, the invention provides a cell-based or multiplexed platform for monitoring the activity of enzymes, e.g., proteases such as viral proteases.

Abstract: Methods of producing a bioplastic are disclosed. Furthermore, chimeric polypeptides useful to transport polyhydroxyalkanoates (PHAs) are disclosed, as are polynucleotides that code for the chimeric polypeptides, cells harboring the chimeric polypeptides and methods of transporting PHAs.

Abstract: The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.

Abstract: Aggregates are calculated from a data stream in which data is sent in a sequence of tuples, in which each tuple comprises an item identifier and a timestamp indicating when the tuple was transmitted. The tuples may arrive at a data receiver out-of-order, that is, the sequence in which the tuples arrive are not necessarily in the same sequence as their corresponding timestamps. In calculating aggregates, more recent data may be given more weight by a decay function which is a function of the timestamp associated with the tuple and the current time. The statistical characteristics of the tuples are summarized by a set of linear data summaries. The set of linear data summaries are generated such that only a single linear data summary falls between a set of boundaries calculated from the decay function and a set of timestamps. Aggregates are calculated from the set of linear data summaries.

Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:

Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.

Abstract: A compound having formula I is useful for treating a neurodegenerative disease: R1 is an C1-12 organyl group; is a C1-12 heterocyclic ring system containing 5 to 12 ring atoms and up to three heteroatoms individually selected from the group consisting of N, O, S, and Se; R2 are C1-12 organyl groups; R7, R8 are each independently, hydrogen (H), hydroxyl, oxo (i.e., carbonyl), C1-8 alkyl, C1-8 alkoxyl, C2-8 alkenyl, C2-10 alkynyl, C5-7 cycloalkyl, C5-7 cycloalkenyl, halo, C1-4 aldehyde, or —NR4q where R4 is H, C1-8 alkyl, C2-8 alkenyl, C4-8 cycloalkyl, C4-8 cycloalkenyl, or C6-10 aryl; o is 0, 1, 2, 3, or 4; A is a C6-12 aryl group, C5-12 heteroaryl group, or an optionally substituted 3-hydroxypyridin-4(1H)-one; p is an integer from 1 to 6; and Zm is absent or a divalent linking moiety; and m is an integer representing the number of time Z is repeated.

Abstract: A system and method is provided for the use of the ion current signal characteristics for onboard cycle-by-cycle, cylinder-by-cylinder measurement. The system may also control the engine operating parameters based on a predicted NOx emission level, CO emission level, CO2 emission level, O2 emission level, unburned hydrocarbon (HC) emission level, cylinder pressure, or a cylinder temperature measurement according to characteristics of the ion current signal.

Abstract: ‘Osorno’ is a new blueberry cultivar of primarily Vaccinium corymbosum. The rest of its parentage is from V. darrowii (13.3%), V. angustifolium (3.8%), V. tenellum (<1%), and V. ashei (<1%). It is a highly productive cultivar with exceptional fresh fruit quality. It is likely best adapted to the northern highbush production areas where winters are not severe, such as central Chile and the Pacific Northwest, but it is recommended for further trial in colder production regions such as Michigan. Plants of ‘Osorno’ are vigorous and upright, although the canes can be lax when loaded with fruit. Canes are numerous, moderately branched and the fruit are well exposed. Its berries are large, have small, dry picking scars, light blue color, and excellent firmness and flavor. Its fruit held up extremely well in the unseasonably hot summer of 2012, when temperatures routinely exceeded 30 C.