Abstract: The present invention provides methods and compositions for the diagnosis, prognosis and treatment of chronic lymphocytic leukemia (CLL). The invention also provides methods of identifying anti-CLL agents.

Abstract: A fuel cell comprising a proton transporting membrane is provided. The proton transporting membrane comprises a polyelectrolyte film comprising a multilayer comprising an interpenetrating network of a net positively charged polyelectrolyte polymer comprising repeat units with at least two fluorine atoms and a net negatively charged polyelectrolyte polymer comprising repeat units with at least two fluorine atoms, and further comprising a fluorinated counterion within the multilayer.

Abstract: Water-soluble dimethyl amino ethyl ether psoralens useful in the treatment of proliferative skin disorders, microbial infections and diseases, disorders of the blood and bone marrow of mammals and in microbiocidal compositions for sterilization of blood and blood products and surgical implants and inhibition of microbial growth in industrial applications are provided.

Abstract: A miniature microphone, comprising a diaphragm, supported for displacement in response to acoustic waves, from which a plurality of projections extend; a plurality of projections extending from a surface; a body, supporting the surface to maintain the plurality of projections from the diaphragm and the plurality of projections from the surface in close proximity; and an electromagnetic sensor adapted to sense an electromagnetic interaction between the plurality of projections from the diaphragm and the plurality of projections from the surface and produce an electrical signal in response thereto. The interaction may be detected substantially without inducing a force which tends to substantially displace the diaphragm, since the electrostatic force is substantially parallel to the diaphragm surface.

Abstract: Particular aspects show that the signal peptide remains intact on the mature CD18 molecule on ruminant leukocytes rendering these cells susceptible to cytolysis by Lkt. Comparative amino acid sequence analysis of the signal peptide of CD18 of eight ruminants and five non-ruminants revealed that the ruminant CD18 signal peptides contain ‘cleavage-inhibiting’ glutamine (Q), compared to ‘cleavage-conducive’ glycine in non-ruminants, at position ?5 relative to the cleavage site. Mutagenesis of Q at position ?5 of the bovine CD18 signal peptide to G resulted in the abrogation of Lkt-mediated cytolysis of transfectants expressing bovine CD18 carrying the Q(?5)G mutation. Provided is novel technology to clone cattle and other ruminants expressing CD18 without the signal peptide on their leukocytes, providing ruminants that are less susceptible to M. haemolytica. Methods for treating conditions and/or diseases associated with M. haemolytica (e.g.

Abstract: Significance of biological pathway in disease state is predicted by (a) providing expression level data for a plurality of biomolecules differentially expressed in a disease state, compared with same biomolecules expressed in a non-diseased state: (b) determining presence probability of the biomolecules in disease state; (c) determining effect of each biomolecule from the plurality of biomolecules on the expression of different downstream biomolecules within pathway to provide perturbation factor for each biomolecule in the pathway; (d) combining statistical significance of differentially expressed biomolecules present in the disease state, with a sum of perturbation factors for all of the biomolecules, generating an impact factor; (e) calculating statistical significance of impact factor based upon determined probability of having statistical significant presence of differentially expressed biomolecules in step (b) and the sum of perturbation factors in step (c); and (f) outputting statistical significance o

Abstract: A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5? non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.

Abstract: Vascular endothelial growth factor alternative splice variants and methods of their use are provided.

Abstract: Compositions and methods relating to the diagnosis and treatment of neuropsychiatric disorders, such as schizophrenia, schizoaffective disorders, and bipolar disorders are disclosed. Also provided are methods for screening therapeutic agents having efficacy for the treatment of such disorders.

Abstract: A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

Abstract: A system for cooling includes a surface to be cooled, at least one film-cooling hole within the surface for allowing a film cooling jet of coolant to reach the surface, each of the at least one film-cooling hole having a diameter and at least two spaced apart flow-aligned blockers positioned downstream of the at least one-film cooling hole, each of the flow-aligned blockers extending upwardly from the surface to assist in preventing hot-gas entrainment and increasing adiabatic effectiveness by confining coolant flow downstream of the at least one film-cooling hole between the blockers.

Abstract: The invention encompasses a recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae, a vaccine comprising the bacterium, and methods of using the bacterium.

Abstract: A method for making a carbon-metal-nitrogen oxygen reducing cathode catalyst, the method comprising mixing a carbon source with a transition metal precursor to form a metal precursor loaded carbon substrate; adding a nitrogen precursor compound to the metal precursor loaded carbon substrate to form a carbon-metal-nitrogen precursor; and pyrolyzing the carbon-metal-nitrogen precursor in a closed vessel, thereby forming an oxygen reducing cathode catalyst. The carbon-metal-nitrogen catalyst requires no precious metal such as Pt, and also provides benefits such as controlled deposition of catalytically active nitrogenous compounds that can increase the catalytic activity of the catalyst when compared to gaseous deposition of nitrogen to the surface of the carbon support.

Abstract: The present invention provides a microchip for performing electrophoresis with pulsed amperometric detection (PAD) for the separation and detection of underivatized carbohydrates, amino acids, sulfur-containing antibiotics, etc. PAD allows for the direct detection of amines, thiols, alcohols and carbohydrates and therefore is a useful technique for the development of electrochemical detection for microchip electrophoresis.

Abstract: A process for the efficient capture of CO2 and sulfur from combustion flue gas streams and gasification based fuel gas mixtures using regenerable and recyclable calcium based sorbents. The regeneration of the calcium sorbent is accomplished by hydrating the sorbent at high temperatures of about 600° C. and a pressure higher than 6 bars to lower the parasitic energy consumption.

Abstract: Embodiments of the invention relate to methods of fabricating semiconductor structures, and to semiconductor structures fabricated by such methods. In some embodiments, the methods may be used to fabricate semiconductor structures of III-V materials, such as InGaN. A semiconductor layer is fabricated by growing sublayers using differing sets of growth conditions to improve the homogeneity of the resulting layer, to improve a surface roughness of the resulting layer, and/or to enable the layer to be grown to an increased thickness without the onset of strain relaxation.

Abstract: A nanoparticle including a polysiloxane base having an exterior surface and having a photosensitizer at least partly exposed at its exterior surface, said photosensitizer being secured to the exterior surface by loading the photosensitizer onto the surface after formation of the polysiloxane base of the nanoparticle. The nanoparticle may have tumor targeting moieties and may be post loaded with cyanine dye. The nanoparticle preferably includes post loaded moieties providing at least two of tumor specificity, photodynamic properties and imaging capabilities and the photosensitizer is tagged with a radioisotope. A method for preparation of the nanoparticle is also provided.

Abstract: Embodiments of a Low Dropout (LDO) regulator are provided in which an n-channel Metal Semiconductor Field Effect Transistor (MESFET) is utilized as a pass transistor of the LDO regulator. In one embodiment, the LDO regulator is implemented on an integrated circuit die and includes an n-channel Semiconductor-on-lnsulator (SOI) MESFET pass transistor. A voltage applied to a substrate of the SOI MESFET pass transistor is controlled to configure the LDO regulator in either an ultra-low dropout voltage mode or a high Power Supply Rejection (PSR) mode. In another embodiment, the LDO regulator includes an re-channel MESFET pass transistor and a switch that operates to disconnect the MESFET pass transistor from a supply voltage of the LDO regulator when the LDO regulator is desired to be shut off.

Abstract: Different circuit-based implementations of stochastic anti-windup PI controllers are provided for a motor drive controller system. The designs can be implemented in a Field Programmable Gate Arrays (FPGA) device. The anti-windup PI controllers are implemented stochastically so as to enhance the computational capability of FPGA.

Abstract: A telescoping box includes a lid. The upper section of the box includes lids which are frictionally engagable therewith. The lids include speaker assemblies as part of each lid. The lids are removable and include connection points for audio signal sources such as MP3 players.