Abstract: Systems, methods, and platforms for identifying and monitoring cell states are described. In one example, a computer-implemented method includes receiving cell imaging data comprising at least one transmitted light micrograph, generating a cell imaging dataset comprising time course data of transmitted light micrographs collected at an interval over a time, applying a machine learning model configured to analyze the cell imaging dataset to build a plurality of profiles of cell states, and identifying a cell state based on the plurality of profiles.