Publication number: 20020094336
Abstract: The present invention is based on the identification and characterization of a number of M. tuberculosis derived novel proteins and protein fragments (SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 17-23, 42, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72-86, 88, 90, 92, 94, 141, 143, 145, 147, 149, 151, 153, and 168-171). The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as vaccines and skin test reagents containing the polypeptides. Another part of the invention is based on the surprising discovery that fusions between ESAT-6 and MPT59 are superior immunogens compared to each of the unfused proteins, respectively.
Type:
Application
Filed:
February 20, 2001
Publication date:
July 18, 2002
Applicant:
STATENS SERUM INSTITUT
Inventors:
Peter Andersen, Rikke Nielsen, Thomas Oettinger, Peter Birk Rasmussen, Ida Rosenkrands, Karin Weldingh, Walter Florio