Abstract: Novel heterocyclic derivatives based on N6-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
Type:
Grant
Filed:
July 18, 2007
Date of Patent:
October 8, 2013
Assignee:
USTAV Experimentalni Botaniky Akademie Ved Ceske Republiky
Inventors:
Igor Popa, Jan Holub, René Lenobel, Stefaan Werbrouck, Karel Dolezal, Miroslav Strnad, Marek Zatloukal, Frank J. Massino
Abstract: The invention concerns novel substitution derivatives of N6-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N6-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.
Type:
Grant
Filed:
December 29, 2003
Date of Patent:
February 21, 2012
Assignee:
Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky
Inventors:
Karel Dolezal, Igor Popa, Marek Zatloukal, René Lenobel, Dana Hradecká, Borivoj Vojtesek, Stjepan Uldrijan, Petr Mlejnek, Stefaan Werbrouck, Miroslav Strnad
Abstract: Heterocyclic derivatives based on N6-substituted adenine of, e.g.,a formula: wherein R2 is hydrogen, R6 is R6?-X, X is —NH—, and R6? is substituted phenyl or substituted benzyl. The derivatives possess anticancer, mitotic, imunosuppressive and antisenescent properties for plant, animal and human cells, and methods of their preparation are disclosed. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
Type:
Grant
Filed:
August 1, 2002
Date of Patent:
October 9, 2007
Assignee:
Ústav experimentálni botaniky Akademie ved Ceské republiky
Inventors:
Karel Dolezal, Igor Popa, Jan Holub, René Lenobel, Stefaan Werbrouck, Miroslav Strnad, Marek Zatloukal