Abstract: There are provided novel 14-functionalized 8,19-oxido steroids possessing 14.alpha. or 14.beta.-hydroxy, 14.alpha. and 14.beta.-acetoxy, 14.alpha.,15.alpha.-oxido or 14.beta.,15.beta.-oxido groups or a double bond in position 14 as well as processes for preparing such compounds. These compounds can be readily converted into the corresponding 14.beta.-hydroxycardenolides, 19-oxygenated cardenolides, 19-norcardenolides and unsaturated cardenolides.
Abstract: Novel compounds of the formula ##STR1## useful as pharmaceutical compounds are disclosed. Processes are also disclosed for their preparation.
Abstract: There are provided novel 19,8-lactone and lactol steroids derivatives having the formula ##STR1## wherein A and B represent 14- or 15-carbon atoms, respectively, which are either linked by a double bond, or which carry an .alpha.- or .beta.-oxido or a 14.alpha.- or .beta.-hydroxy group in which case B is a methylene group; Y is .dbd.O; 3.alpha. or 3.beta.-OH;.sup.2 H;.sup.3 H; O-alkyl; or O-acyl; H; R' is OH, .dbd.O or acetoxy, the 5-hydrogen atom is either in the .alpha. or .beta.-position; there is an optional double bond in position 4(5); 5(6) and 6(7); and R is selected from the group consisting of O-acyl; ##STR2## AND CN, wherein alkyl is tetrahydropyranyl, lower alkyl, preferably methyl or ethyl, or a substituted methyl wherein the substituent is selected from the group consisting of phenyl, halogen, preferably chlorine and bromine, methoxy, CH.sub.2 .dbd.CH and HC.tbd.
Abstract: Novel steroids of the formula ##STR1## Also there are provided processes for preparing such compounds. The new compounds are useful as intermediates in the preparation of known cardenolides; various of the compounds have other uses as blocking agents.
Abstract: There are provided novel 14,19-dioxygenated steroid compounds and their 14-dehydro analogs, as well as processes for preparing such compounds. The above compounds are useful as intermediates in the preparation of other steroids, which in turn, may be converted into valuable pharmaceutical agents.
Abstract: There are provided novel 4,6,8(14)-triene-steroids as well as processes for preparing such compounds. The above compounds are useful as intermediates in the preparation of other steroids, which in turn, may be converted into valuable pharmaceutical agents.