Abstract: A single screw clamping tuner is provided for clamping and tuning a string of a stringed musical instrument. The tuner includes one and only one externally threaded screw which accomplishes both the clamping of a string end and the tuning of the string. The tuner includes a housing having a channel defined therein. A slider is slidably received in the channel and receives the string end therein. The one and only one screw has a first portion threadably engaged with the slider for clamping the string end against the slider. A tuning knob is threadably engaged with the one and only one screw for adjusting a position of the screw and the slider relative to the housing when the tuning knob is rotated relative to the housing to tune the string. An integral wrench carried by the tuning knob is selectively engagable with a head of the screw for rotating the screw relative to the slider to clamp or unclamp the string end against the slider.