Patents Assigned to StemCells California, Inc.
  • Cultures of GFAPnestincells that differentiate to neurons
    Patent number: 8501467
    Abstract: Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures. Depending on the culture conditions, the cells can be induced to differentiate to neurons or glial cells. The cultures can be expanded over a large number of passages during several months, and survive, express an astroglial phenotype and integrate well after transplantation into both neonatal and adult rat forebrain.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: August 6, 2013
    Assignee: StemCells California, Inc.
    Inventors: Lars Wahlberg, Kenneth Campbell, Charlotta Skogh, Cecilia Eriksson, Klas Wictorin
  • Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Patent number: 7381561
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagents that bind to cell surface markers are provided.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: June 3, 2008
    Assignee: StemCells California, Inc.
    Inventors: Nobuko Uchida, Alexandra Capela
  • Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Patent number: 7217565
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: May 15, 2007
    Assignee: StemCells California, Inc.
    Inventors: David W. Buck, Nobuko Uchida, Irving Weissman
  • Compositions of enriched central nervous system stem cell and progenitor cell populations
    Patent number: 7153686
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: December 26, 2006
    Assignee: Stemcells California, Inc.
    Inventors: Nobuko Uchida, David W. Buck, Irving Weissman
  • In vivo screening methods using enriched neural stem cells
    Patent number: 7105150
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Grant
    Filed: February 23, 2001
    Date of Patent: September 12, 2006
    Assignee: StemCells California, Inc.
    Inventors: David W. Buck, Nobuko Uchida, Irving Weissman
  • Use of collagenase in the preparation of neural stem cell cultures
    Patent number: 7049141
    Abstract: The invention provides a method for using collagenase to dissociate neural stem cells in neural stem cell cultures. The collagenase treatment results in an increased cell viability and an increased number of proliferated neural stem cells over time.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: May 23, 2006
    Assignee: StemCells California, Inc.
    Inventor: Nobuko Uchida
  • Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
    Patent number: 7037719
    Abstract: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: May 2, 2006
    Assignee: StemCells California, Inc.
    Inventors: David W. Buck, Nobuko Uchida, Irving Weissman
  • Cultures of human CNS Neural stem cells
    Patent number: 6777233
    Abstract: The invention provides a method for determining the effect of a biological agent comprising contacting a cell culture with a biological agent. The cell culture of the invention contains a culture medium containing one or more preselected growth factors effective for inducing multipotent central nervous system (CNS) neural stem cell proliferation. The cell culture also contains, suspended in the culture medium, human multipotent CNS neural stem cells that are derived from primary CNS neural tissue that have a doubling rate faster than 30 days.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: August 17, 2004
    Assignee: StemCells California, Inc.
    Inventor: Melissa Carpenter