Patents Assigned to Stemedica Cell Technologies, Inc.
  • METHOD OF TREATING MENTAL STATE IN PATIENTS AFTER ISCHEMIC BRAIN INJURY WITH ISCHEMIC TOLERANT ALLOGENEIC MESENCHYMAL BONE MARROW CELLS
    Publication number: 20170027990
    Abstract: A method of treating the mental state of subjects with significant neurological, functional and/or motor impairment from an ischemic stroke. The method comprises a step of intravenously dosing ischemic tolerant allogeneic mesenchymal bone marrow cells itMSCs to subjects with ischemic stroke.
    Type: Application
    Filed: August 21, 2015
    Publication date: February 2, 2017
    Applicant: Stemedica Cell Technologies, Inc.
    Inventor: Nikolai Tankovich
  • ISCHEMIC TOLERANT CELLS AND CELLULAR FACTORS IN THE TREATMENT OF PERIPHERAL ARTERY DISEASE
    Publication number: 20160287638
    Abstract: A method for treatment of peripheral arterial disease conditions comprising systemically administering an effective amount of therapeutic stem cells. Included within the scope of the invention is intravenous administration of a therapeutic amount of ischemic tolerant mesenchymal stem cells in the treatment of peripheral arterial disease.
    Type: Application
    Filed: April 2, 2015
    Publication date: October 6, 2016
    Applicant: Stemedica Cell Technologies, Inc.
    Inventors: Stephen E. Epstein, Alex Kharazi, Nikolai Tankovich, Sergey Sikora
  • SANDWICHED BIODEGRADABLE MICRONEEDLE
    Publication number: 20160287668
    Abstract: A microneedle device for delivering therapeutic ingredients to the dermis or epidermis. The device contains biodegradable microneedles, which extend from a backing, and are sandwiched between a cap film and a film which is coextensive with the tips of the microneedles and the spaces on the backing between the microneedles.
    Type: Application
    Filed: October 6, 2014
    Publication date: October 6, 2016
    Applicant: Stemedica Cell Technologies, Inc.
    Inventor: Nikolai Tankovich
  • DIFFERENTIATION OF RPE PROGENITORS INTO NEURON-LIKE CELLS
    Publication number: 20160222349
    Abstract: A method of permanently culturing RPE cells under hypoxia, and differentiating the RPE cells into neuronal like cells.
    Type: Application
    Filed: March 29, 2016
    Publication date: August 4, 2016
    Applicant: Stemedica Cell Technologies, Inc.
    Inventor: Ludmilla Kharazi
  • Transgenic therapeutic stem cells and methods for their use and manufacture
    Patent number: 9080184
    Abstract: The invention relates to transgenic stem cells for therapeutic use. Stem cells according to the invention comprise at least one therapeutic trans gene that is expressed when transplanted to a subject. Methods of use and manufacturing the transgenic stem cells of the invention are also contemplated, including the use of transiently transgenic G-CSF bone marrow stem cells for treating the penumbra of ischemic tissues such as central nervous system tissues.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: July 14, 2015
    Assignee: Stemedica Cell Technologies, Inc.
    Inventors: Alex Kharazi, M G Muralidhar, Grigory Vertelov
  • Compositions of stem cells and stem cell factors and methods for their use and manufacture
    Patent number: 8790638
    Abstract: Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: July 29, 2014
    Assignee: Stemedica Cell Technologies, Inc.
    Inventors: Nikolai Tankovich, Alexander Kharazi, Chih-Min Lin
  • Cellular scaffold
    Patent number: 8709081
    Abstract: A cellular scaffold that is suitable for tissue regeneration, cell culture and in vitro assays. The invention relates to a layered cell scaffold that is seeded with mesenchymal and ectodermal cells. The layered cellular scaffold comprises an inoculum of mesenchymal cells and ectodermal cells positioned between two opposing scaffolds in a sandwich configuration. The layered cell scaffold provides a functional skin equivalent that is suitable for transplantation and in vitro cell-based assays.
    Type: Grant
    Filed: October 2, 2011
    Date of Patent: April 29, 2014
    Assignee: Stemedica Cell Technologies, Inc.
    Inventors: Alexander Kharazi, Ludmilla Kharazi, Nikolai Tankovich
  • STEM CELLS AND METHODS FOR INCORPORATING ENVIRONMENTAL FACTORS AS A MEANS FOR ENHANCING STEM CELL PROLIFERATION AND PLASTICITY
    Publication number: 20130177537
    Abstract: Disclosed are methods for expanding stem cells that use a unique combination of environmental factors and cell culture conditions to produce stem cells having enhanced proliferation and differentiation characteristics. Also disclosed are methods for enhancing the engraftment and/or migratory potential of stem cells for therapeutic uses. Stem cells having unique proliferation, differentiation, migratory and engraftment characteristics are also disclosed.
    Type: Application
    Filed: March 6, 2013
    Publication date: July 11, 2013
    Applicant: STEMEDICA CELL TECHNOLOGIES, INC.
    Inventor: Stemedica Cell Technologies, Inc.
  • Cellular scaffold
    Patent number: 8105380
    Abstract: A cellular scaffold that is suitable for tissue regeneration, cell culture and in vitro assays. The invention relates to a layered cell scaffold that is seeded with mesenchymal and ectodermal cells. The layered cellular scaffold comprises an inoculum of mesenchymal cells and ectodermal cells positioned between two opposing scaffolds in a sandwich configuration. The layered cell scaffold provides a functional skin equivalent that is suitable for transplantation and in vitro cell-based assays.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: January 31, 2012
    Assignee: Stemedica Cell Technologies, Inc.
    Inventors: Alexander Kharazi, Ludmila Kharazi