Patents Assigned to Stemline Therapeutics, Inc.
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Publication number: 20240115677Abstract: Provided herein are cancer stem cell targeted cancer vaccines and methods for treating and vaccinating against cancer. Also contained herein are regimens by which cancer stem cell targeted cancer vaccines are administered, such regimens comprising peptides, compositions, immunomodulatory agents, and emulsifiers. Also provided are the patient populations to which the regimens are to be administered, and the dosages, schedules, and route of administration for the regimens.Type: ApplicationFiled: April 28, 2023Publication date: April 11, 2024Applicant: Stemline Therapeutics, Inc.Inventors: Ivan Bergstein, Christopher Brooks, Thomas P. Cirrito
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Publication number: 20230374152Abstract: Provided herein are methods for treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a peptide derived from the EphA2 protein and/or the IL-13R?2 protein and monitoring the amount of cancer stem cells in the subject. Also provided herein are methods for monitoring the efficacy of an EphA2 peptide-based cancer treatment or an IL-13R?2 peptide-based cancer treatment in a patient with cancer, comprising monitoring the amount of cancer stem cells in the subject prior to, during, and/or following cancer treatment of a patient.Type: ApplicationFiled: August 4, 2022Publication date: November 23, 2023Applicant: Stemline Therapeutics, Inc.Inventors: Thomas P. Cirrito, Ivan Bergstein, Christopher Brooks
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Publication number: 20230355709Abstract: Provided herein are improved formulations of tagraxofusp for lyophilization used to manufacture stable formulations of tagraxofusp for intravenous injection.Type: ApplicationFiled: June 8, 2023Publication date: November 9, 2023Applicant: Stemline Therapeutics, Inc.Inventors: Joan Connolly, Frederick Erickson, Madhav Kamat, Jennifer Wasserman, James Zabrecky
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Publication number: 20230324391Abstract: The present invention is directed to methods of monitoring cancer stem cells in patients undergoing cancer therapy to determine whether the cancer therapy is an effective cancer therapy. The present invention relates to methods for monitoring the amount of cancer stem cells prior to, during, and/or following cancer treatment of a patient. In particular, the methods provide measuring the amount of cancer stem cells i) in a sample obtained from a patient and/or ii) in a patient via in vivo imaging, e.g. at different time points before, during or after a treatment regimen for cancer. The change in amount of cancer stem cells over time allows the physician to judge the effectiveness of the treatment regimen and then to decide to continue, alter, or halt the treatment regimen if need be. The present invention also provides kits for monitoring cancer stem cells prior to, during, and/or following cancer treatment of a patient.Type: ApplicationFiled: November 11, 2022Publication date: October 12, 2023Applicant: Stemline Therapeutics, Inc.Inventors: Ivan Bergstein, Thomas P. Cirrito
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Patent number: 11672847Abstract: Provided herein are cancer stem cell targeted cancer vaccines and methods for treating and vaccinating against cancer. Also contained herein are regimens by which cancer stem cell targeted cancer vaccines are administered, such regimens comprising peptides, compositions, immunomodulatory agents, and emulsifiers. Also provided are the patient populations to which the regimens are to be administered, and the dosages, schedules, route of administration for the regimens.Type: GrantFiled: October 10, 2019Date of Patent: June 13, 2023Assignee: Stemline Therapeutics, Inc.Inventors: Ivan Bergstein, Christopher Brooks, Thomas P. Cirrito
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Publication number: 20230158005Abstract: Provided herein are methods of using substituted azole dione compounds for treatment of viral infections.Type: ApplicationFiled: March 22, 2021Publication date: May 25, 2023Applicant: Stemline Therapeutics, Inc.Inventors: Janice Chen, Christopher Brooks, Ivan Bergstein
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Publication number: 20220202824Abstract: Disclosed herein are methods for treating centronuclear myopathies, such as myotubular myopathy, in a subject in need thereof, comprising administering to the subject in need thereof an effective amount of 3-{[(3S)-4-(6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)morpholin-3-yl]methyl}-N,N,1-trimethyl-1H-indole-5-carboxamide and/or a pharmaceutically acceptable form thereof.Type: ApplicationFiled: September 13, 2019Publication date: June 30, 2022Applicant: Stemline Therapeutics, Inc.Inventors: Enrique Poradosu, Thomas Bartholomew Crabbe
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Publication number: 20220001020Abstract: The present invention provides methods for treating or inhibiting a myeloproliferative neoplasm (MPN) in a subject in need thereof, comprising administering to the subject a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) and one or more Jak inhibitors and/or one or more hypomethylating agents.Type: ApplicationFiled: October 30, 2019Publication date: January 6, 2022Applicant: Stemline Therapeutics, Inc.Inventor: Ivan Bergstein
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Publication number: 20210388354Abstract: A method of manipulating the fate of a cell, which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding RNA species (cuR), (b) a modified cuR, or (c) a compound that modifies or affects cuR, under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of RNA:RNA or RNA:DNA or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained.Type: ApplicationFiled: January 25, 2021Publication date: December 16, 2021Applicant: Stemline Therapeutics, Inc.Inventor: Ivan Bergstein
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Publication number: 20210361744Abstract: The present disclosure provides, in part, a method of treating an autoimmune disease in a subject by reducing the number of pDCs through administration of a human interleukin-3 (IL-3)-diphtheria toxin conjugate (DT-IL3). The disclosure also generally relates to methods of monitoring the effectiveness of therapy in subjects receiving DT-IL3 for treating an autoimmune disease, and methods of determining continuing treatment of subjects receiving DT-IL3 for treating an autoimmune disease. The disclosure also provides pharmaceutical compositions of DT-IL3 for use in such methods.Type: ApplicationFiled: April 26, 2019Publication date: November 25, 2021Applicant: Stemline Therapeutics, Inc.Inventor: Ivan Bergstein
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Publication number: 20210355226Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R?) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3R?-expressing cell population, the methods comprising contacting a population of IL3R?-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3R?. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3R? chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3R?-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3R?.Type: ApplicationFiled: December 23, 2020Publication date: November 18, 2021Applicant: Stemline Therapeutics, Inc.Inventor: Ivan Bergstein
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Publication number: 20210093701Abstract: Provided herein are cancer stem cell targeted cancer vaccines and methods for treating and vaccinating against cancer. Also contained herein are regimens by which cancer stem cell targeted cancer vaccines are administered, such regimens comprising peptides, compositions, immunomodulatory agents, and emulsifiers. Also provided are the patient populations to which the regimens are to be administered, and the dosages, schedules, route of administration for the regimens.Type: ApplicationFiled: October 10, 2019Publication date: April 1, 2021Applicant: Stemline Therapeutics, Inc.Inventors: Ivan Bergstein, Christopher Brooks, Thomas P. Cirrito
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Patent number: 10906979Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R?) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3R?-expressing cell population, the methods comprising contacting a population of IL3R?-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3R?. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3R? chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3R?-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3R?.Type: GrantFiled: April 24, 2019Date of Patent: February 2, 2021Assignee: Stemline Therapeutics, Inc.Inventor: Ivan Bergstein
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Publication number: 20200330566Abstract: The present invention provides methods for stabilizing, reducing or eliminating cancer cells. In particular, the present invention provides prophylactically and/or therapeutically effective regimens for the prevention, treatment and/or management of cancer, the regimens comprising administering one or more cancer therapies to a subject to reduce a cancer cell population. The therapy(ies) in the prophylactically and/or therapeutically effective regimen can be administered at a lower dose than currently used or known to one of skill in the art and/or for a longer period of time and/or more frequently than currently administered or known to one of skill in the art.Type: ApplicationFiled: November 25, 2019Publication date: October 22, 2020Applicant: Stemline Therapeutics, Inc.Inventors: Ivan Bergstein, Thomas P. Cirrito
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Patent number: 10485858Abstract: Provided herein are cancer stem cell targeted cancer vaccines and methods for treating and vaccinating against cancer. Also contained herein are regimens by which cancer stem cell targeted cancer vaccines are administered, such regimens comprising peptides, compositions, immunomodulatory agents, and emulsifiers. Also provided are the patient populations to which the regimens are to be administered, and the dosages, schedules, route of administration for the regimens.Type: GrantFiled: May 15, 2013Date of Patent: November 26, 2019Assignee: Stemline Therapeutics, Inc.Inventors: Ivan Bergstein, Christopher Brooks, Thomas P. Cirrito
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Publication number: 20190315874Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R?) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3R?-expressing cell population, the methods comprising contacting a population of IL3R?-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3R?. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3R? chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3R?-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3R?.Type: ApplicationFiled: April 24, 2019Publication date: October 17, 2019Applicant: STEMLINE THERAPEUTICS, INC.Inventor: Ivan Bergstein
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Patent number: 10316098Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R?) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3R?-expressing cell population, the methods comprising contacting a population of IL3R?-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3R?. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3R? chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3R?-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3R?.Type: GrantFiled: December 7, 2017Date of Patent: June 11, 2019Assignee: Stemline Therapeutics, Inc.Inventor: Ivan Bergstein
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Publication number: 20180364237Abstract: The present invention is directed to methods of monitoring cancer stem cells in patients undergoing cancer therapy to determine whether the cancer therapy is an effective cancer therapy. The present invention relates to methods for monitoring the amount of cancer stem cells prior to, during, and/or following cancer treatment of a patient. In particular, the methods provide measuring the amount of cancer stem cells i) in a sample obtained from a patient and/or ii) in a patient via in vivo imaging, e.g. at different time points before, during or after a treatment regimen for cancer. The change in amount of cancer stem cells over time allows the physician to judge the effectiveness of the treatment regimen and then to decide to continue, alter, or halt the treatment regimen if need be. The present invention also provides kits for monitoring cancer stem cells prior to, during, and/or following cancer treatment of a patient.Type: ApplicationFiled: August 22, 2018Publication date: December 20, 2018Applicant: Stemline Therapeutics, Inc.Inventors: Ivan Bergstein, Thomas P. Cirrito
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Patent number: 9873743Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R?) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3R?-expressing cell population, the methods comprising contacting a population of IL3R?-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3R?. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3R? chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3R?-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3R?.Type: GrantFiled: November 3, 2016Date of Patent: January 23, 2018Assignee: Stemline Therapeutics, Inc.Inventor: Ivan Bergstein
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Publication number: 20170152321Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R?) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3R?-expressing cell population, the methods comprising contacting a population of IL3R?-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3R?. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3R? chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3R?-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3R?.Type: ApplicationFiled: November 3, 2016Publication date: June 1, 2017Applicant: Stemline Therapeutics, Inc.Inventor: Ivan Bergstein