Abstract: There is provided a compound of Formula I wherein X, Y and Z are each independently of each other an optional linker group; R1 is a ring system; R2 is selected from hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO2) and halogens; R3 and R4 are independently selected from H and hydrocarbyl, ring A and B are independently optionally further substituted.
Type:
Grant
Filed:
December 4, 2006
Date of Patent:
July 27, 2010
Assignee:
Sterix Ltd.
Inventors:
Lok Wai Lawrence Woo, Toby Jackson, Christian Bubert, Atul Purohit, Michael John Reed, Barry Victory Lloyd Potter
Abstract: There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C?O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
Type:
Grant
Filed:
August 22, 2005
Date of Patent:
April 22, 2008
Assignee:
Sterix, Ltd.
Inventors:
Barry Victor Lloyd Potter, Lok Wai Lawrence Woo, Atul Purohit, Michael John Reed, Oliver Brook Sutcliffe, Christian Bubert
Abstract: There is provided use of a compound of Formula XI: wherein R3 is a sulphamate group and at least of R1 or R2 is a thioether group as disclosed by the present specification, capable of inhibiting steroid sulphatase.
Type:
Grant
Filed:
February 14, 2003
Date of Patent:
March 11, 2008
Assignee:
Sterix Ltd.
Inventors:
Barry Victor Lloyd Potter, Michael John Reed, Graham Keith Packham, Matthew Paul Leese
Abstract: A compound is described. In particular, a non-steroidal sulphamate compound is described. The compound is suitable for use as an inhibitor of oestrone sulphatase. The compound is of general Formula (A), wherein R1–R6 are independently selected from H, halo, hydroxy, sulphamate, alkyl and substituted variants or salts thereof; but wherein at least one of R1–R6 is a sulphamate group; and wherein X is any one of S, NH, a substituted N, CH2, or a substituted C.
Type:
Grant
Filed:
November 17, 2004
Date of Patent:
April 10, 2007
Assignee:
Sterix, Ltd.
Inventors:
Michael John Reed, Barry Victor Lloyd Potter
Abstract: The instant invention relates to sulphamate compounds of formula I, wherein A represents a ring structure, B represents a ring structure, D a ring structure, C is a bond, E is a link joining ring structure B to the ring structure D, X represents a suitable first group, and Y represents a suitable second group; wherein one ring of the compound is a phenolic ring; and wherein any one of ring structures A, B and D has bound thereto a sulphamate group.
Type:
Grant
Filed:
December 20, 2002
Date of Patent:
October 31, 2006
Assignee:
Sterix Ltd.
Inventors:
Michael John Reed, Barry Victor Lloyd Potter
Abstract: A method for controlling estrone or estrodiol production comprising administering a ring system compound comprising a sulphamic acid ester group; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2); and wherein if the sulphamic acid ester group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (EC 3.1.6.2) at a pH 7.4 and 37° C. it provides a Km value of less than 50 &mgr;M. A method to target the estrogen metabolic pathway comprising administering a ring system compound comprising a sulphamic acid ester group; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2); and wherein if the sulphamic acid ester group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (EC 3.1.6.2) at a pH 7.4 and 37° C. it provides a Km value of less than 50 &mgr;M.
Type:
Grant
Filed:
February 21, 2002
Date of Patent:
January 13, 2004
Assignee:
Sterix Ltd.
Inventors:
Michael John Reed, Barry Victor Lloyd Potter