Patents Assigned to Sterling Biotech Limited
  • Publication number: 20110282074
    Abstract: This invention relates to an improved process for preparing substantially pure simvastatin (I), chemically known as (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2-H-pyran-2-yl]ethyl]-3 ,7-dimeth-yl-1,2,3,7,8,8a-Hexahydronaphthalen-1-yl2,2-dimethyl butanoate, which comprises of: a) treating lovastatin (II) with an alkali metal hydroxide in a chosen suitable alcoholic solvent followed by relactonization to obtain the diol lactone intermediate (III) in a single vessel. b) selective silylation of 4-hydroxy group of diol lactone intermediate (III) with a chosen suitable silylating reagent to obtain mono silylated intermediate diol lactone (IV).
    Type: Application
    Filed: July 8, 2010
    Publication date: November 17, 2011
    Applicant: Sterling Biotech Research Center a Corporate Research Centre of Sterling Biotech Limited
    Inventors: Sugata Chatterjee, Ajay Singh Rawat, Neeraj Kumar, Jetti Rajanikanth, Kundan Singh Shekhawat, Jigar H. Shah, P. Venkateswarlu
  • Publication number: 20100105916
    Abstract: A process for preparing highly pure donepezil, particularly donepezil hydrochloride, is provided comprising hydrogenating compound 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methyl-piperidine or its hydrochloride salt with a noble metal catalyst or a derivative thereof, in the presence of at least one additive, wherein the additive contains at least one heteroatom, e.g., a sulfur, phosphorous, or nitrogen heteroatom.
    Type: Application
    Filed: April 23, 2009
    Publication date: April 29, 2010
    Applicant: Sterling Biotech Limited
    Inventors: Raju Mahadev Kharatkar, Sachin Vinayakrao Pande, Nilesh Liladhar Bonde, Godfree Pavalu Fernandes, Sugata Chatterjee
  • Publication number: 20100022777
    Abstract: An improved, scalable, and environmentally friendly manufacturing procedure for the preparation of E-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde, which is a key early intermediate used in the preparation of montelukast sodium, and the compound prepared by such a process.
    Type: Application
    Filed: October 29, 2008
    Publication date: January 28, 2010
    Applicant: Sterling Biotech Limited
    Inventors: Sugata Chatterjee, Ajay Singh Rawat, Neeraj Kumar, Mukesh Chavda, Rushikesh Kadu