Abstract: The present invention is directed to a method of labeling a protein conjugate with a radionuclide to form a radioconjugate comprising reacting:(a) the radionuclide; and(b) the protein conjugate in an acetate buffer for a time period and under conditions sufficient to form said radioconjugate.Preferably, the protein conjugate is comprised of a complexing agent moiety and a free epsilon amino group-containing protein moiety. The completing agent moiety is preferably a terpyridine analog. The terpyridine analog is preferably TMT.Preferably, the free epsilon amino group-containing protein moiety is an immunoreactive protein. The immunoreactive protein is preferably the monoclonal antibody ING-1.In a preferred embodiment, the protein conjugate is TMT-ING-1, and the radionuclide is .sup.90 Y.In a further preferred embodiment, the radioconjugate is chelated to greater than 98 percent of the radionuclide.

Abstract: In accordance with this invention, there is provided a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, and a method for the preparation thereof. The polymer is particularly useful in therapeutic and diagnostic imaging compositions and as an antistatic agent.

Abstract: A hypodermic syringe holder adapted to receive a disposable ampoule and eject it in an axial direction. The holder comprises a plunger element, a holding element and a disposable hollow cylindrical frame portion.

Abstract: In accordance with this invention, there is provided a closure arrangement for medication containers comprising an elastomeric stopper comprising a tear-away member which blocks a passageway defining a conical luer taper and a cap comprising means for engaging the tear-away member, whereby the engaged tear-away member can be readily torn away by a user by rotating the cap or by pulling the cap off the container in an axial direction. The closure arrangement reduces the risk of particulate contamination associated with stoppers adapted to be ruptured with a luer nozzle.