Patents Assigned to Sterling Winthrop
  • Patent number: 5183813
    Abstract: A pharmaceutical composition for treating cardiac arrhythmias or inhibiting ventricular tachycardias comprises an effective amount of a compound having the structural formula: ##STR1## or a pharmaceutically acceptable salt thereof; wherein at least one R.sup.1 is H and the other R.sup.1 is H, alkyl, halogen, alkoxy or alkylthio;R.sup.2 is alkyl containing at least 2 carbon atoms, benzyl or aryl;R.sup.3 is alkyl or aryl; andR.sup.a and R.sup.b taken together with the carbon and nitrogen atoms to which they are attached represent a heterocyclic group; together with a non-toxic pharmaceutically acceptable carrier. The compounds and compositions are useful in methods of treating cardiac arrhythmias and inhibiting ventricular tachycardias in mammalian subjects.In composition of matter aspect, this invention relates to certain novel 2-(2-iminoethylidene)benzimidazolines and neutral tautomers thereof.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: February 2, 1993
    Assignee: Sterling Winthrop Inc.
    Inventors: Kenneth C. Mattes, Bhaskar R. Venepalli
  • Patent number: 5180749
    Abstract: An aqueous antimicrobial composition comprising from about 10 to about 30 percent by weight of ethyl alcohol, from about 2 to about 5 percent by weight of benzyl alcohol and the remainder to 100% water, and a method of use of the composition for destroying or reducing the number of microbes on a surface contaminated therewith.
    Type: Grant
    Filed: August 22, 1989
    Date of Patent: January 19, 1993
    Assignee: Sterling Winthrop, Inc.
    Inventors: Timothy M. Cusack, Vincent J. Sickora, Robert W. Bender
  • Patent number: 5175155
    Abstract: The method of use of a combination of the antiandrogen (5.alpha.,17.alpha.)-1'-(methylsulfonyl)-1'H-pregn-20-yno[3,2-c]pyrazol-17 -ol (Win 49596) and the 5.alpha.-reductase inhibitor (5.alpha.,17.beta.)-N-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carb oxamide (finasteride) for treating prostate disease in a male mammal and pharmaceutical compositions thereof are disclosed.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: December 29, 1992
    Assignee: Sterling Winthrop Inc.
    Inventors: Paul E. Juniewicz, Bruce M. Berger
  • Patent number: 5141931
    Abstract: 6-Alkyl-5-(6, or 7-quinolinyl)-3-(substituted)-2(1H)-pyridinones useful as cardiotonics are synthesized by reaction of trialkylquinolinylstannanes with 6-alky-5-halo-3-(substituted)-2(1H)-pyridinones. Compositions containing these pyridinones and methods of using them to treat congestive heart failure are provided.
    Type: Grant
    Filed: January 3, 1991
    Date of Patent: August 25, 1992
    Assignee: Sterling Winthrop Inc.
    Inventor: Edward R. Bacon
  • Patent number: 5128339
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: July 7, 1992
    Assignee: Sterling Winthrop Inc.
    Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court
  • Patent number: 5091410
    Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.
    Type: Grant
    Filed: June 10, 1991
    Date of Patent: February 25, 1992
    Assignee: Sterling Winthrop Inc.
    Inventors: Theodore C. Miller, Michael E. Ross
  • Patent number: 4274884
    Abstract: A composition containing organic compounds for plasticizing resins, an emulsifying agent, a thickening and suspending agent and possibly an inert filler and/or water, is applied to an emulsion-painted wallpaper surface and left for several hours to allow the compounds to act on the binder resins in the paint coating. The resulting cohesive, plasticized paint film may then be removed by scoring and removing strips of the film and adhering wallpaper, starting from the score mark, any remaining paint and underlying paper being removed by scraping after possible application of water.
    Type: Grant
    Filed: May 2, 1979
    Date of Patent: June 23, 1981
    Assignee: Sterling Winthrop Group Limited
    Inventor: Jeffery Cartwright
  • Patent number: 4120619
    Abstract: A reciprocating pump for dispensing fluent substances comprises a piston slidable in a cylinder and defining a substance-trapping space at the inner end of the cylinder. Inlet and outlet ports are formed in the piston and connect with the space under the control of a tubular sleeve mounted on a reduced diameter inner end portion of the piston and capable of limited axial movement relative to the piston. Frictional engagement of the sleeve with the wall of the cylinder holds the sleeve stationary upon initial reciprocation of the piston within the cylinder and the piston slides through the sleeve to switch over the porting connections. During the subsequent portion of the stroke of the piston the sleeve and piston move as a unit.
    Type: Grant
    Filed: August 29, 1977
    Date of Patent: October 17, 1978
    Assignee: Sterling-Winthrop Group Limited
    Inventor: Trevor William Blackband