Patents Assigned to Steven M. Sugarman
  • Lipid complexed topoisomerase I inhibitors
    Patent number: 5834012
    Abstract: The present invention is described as a lipid-complexed topoisomerase I inhibitor (TII), for example camptothecin (CPT) preparation that allows for intravenous administration in vivo in clinically relevant lipid:drug ratios. The lipid formulation has in vitro antitumor activity similar to that of the base compound and displays similar cytotoxicity against both MDR-1 negative and positive tumor cells.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: November 10, 1998
    Assignees: Roman Perez-Soler, Steven M. Sugarman, Kenneth R. Poirot
    Inventors: Roman Perez-Soler, Steven M. Sugarman, Kenneth R. Poirot