Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a watersoluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.
Type:
Application
Filed:
October 29, 2021
Publication date:
February 17, 2022
Applicant:
STI Pharma, LLC
Inventors:
David F. COUNTS, Donald P. COX, Anup K. DAM, Michael E. STALHAMER
Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a watersoluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.
Type:
Grant
Filed:
September 13, 2019
Date of Patent:
December 7, 2021
Assignee:
STI Pharma, LLC
Inventors:
David F. Counts, Donald P. Cox, Anup K. Dam, Michael E. Stalhamer
Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a water-soluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.
Type:
Grant
Filed:
June 7, 2012
Date of Patent:
November 5, 2019
Assignee:
STI PHARMA, LLC
Inventors:
David F. Counts, Donald P. Cox, Anup K. Dam, Michael E. Stalhamer
Abstract: The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a watersoluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound.
Type:
Application
Filed:
June 7, 2012
Publication date:
June 5, 2014
Applicant:
STI PHARMA, LLC
Inventors:
David F. Counts, Donald P. Cox, Anup K. Dam, Michael E. Stalhamer