Abstract: Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising a Lelystad Agent-specific nucleotide sequence. Peptides comprising a Lelystad Agent-specific amino acid sequence. Lelystad Agent-specific antibodies.
Type:
Grant
Filed:
August 21, 2002
Date of Patent:
October 19, 2004
Assignee:
Stichting Centraal Diergeneeskundig Instituut
Inventors:
Gert Wensvoort, Catharinus Terpstra, Joannes Maria Anthonis Pol, Robertus Jacobus Maria Moormann, Johanna Jacoba Maria Meulenberg
Abstract: Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising a Lelystad Agent-specific nucleotide sequence. Peptides comprising a Lelystad Agent-specific amino acid sequence. Lelystad Agent-specific antibodies.
Type:
Grant
Filed:
May 5, 2000
Date of Patent:
September 24, 2002
Assignee:
Stichting Centraal Diergeneeskundig Instituut
Inventors:
Gert Wensvoort, Catharinus Terpstra, Joannes Maria Anthonis Pol, Robertus Jacobus Maria Moormann, Johanna Jacoba Maria Meulenberg
Abstract: A deletion mutant of bovine herpesvirus type 1 which has a deletion in the glycoprotein gE-gene and which may further have a deletion in the thymidine kinase gene and/or the glycoprotein gI-gene, or have an insertion of a heterologous gene is disclosed. Recombinant nucleic acids which encode the gE-gene or a part thereof are also disclosed, in addition to vaccines and a method of treatment.
Type:
Grant
Filed:
October 14, 1997
Date of Patent:
June 11, 2002
Assignee:
Stichting Centraal Diergeneeskundig Instituut
Inventors:
Franciscus Antonius Maria Rijsewijk, Johannes Theodorus van Oirschot
Abstract: Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising a Lelystad Agent-specific nucleotide sequence. Peptides comprising a Lelystad Agent-specific amino acid sequence. Lelystad Agent-specific antibodies.
Type:
Grant
Filed:
November 13, 1996
Date of Patent:
March 6, 2001
Assignee:
Stichting Centraal Diergeneeskundig Instituut
Inventors:
Gert Wensvoort, Catharinus Terpstra, Joannes Maria Anthonis Pol
Abstract: Deletion mutant of bovine herpesvirus type 1 which has a deletion in the glycoprotein gE-gene. The mutant may further have a deletion in the thymidine kinase gene and/or the glycoprotein gI-gene, or have an insertion of a heterologous gene. Recombinant nucleic acid which comprises the gE-gene or a part thereof. Glycoprotein gE, peptides based thereon and complexes of the glycoproteins gE and gI, and antibodies against them. Vaccines and diagnostic kits comprising any one of these materials.
Type:
Grant
Filed:
May 31, 1995
Date of Patent:
August 4, 1998
Assignee:
Stichting Centraal Diergeneeskundig Instituut
Inventors:
Franciscus Antonius Maria Rijsewijk, Johannes Theodorus van Oirschot, Roger Kamiel Maes
Abstract: A deletion mutant of bovine herpesvirus type 1 which has a deletion in the glycoprotein gE-gene and which may further have a deletion in the thymidine kinase gene and/or the glycoprotein gI-gene, or have an insertion of a heterologous gene is disclosed. Recombinant nucleic acids which encode the gE-gene or a part thereof are also disclosed, in addition to vaccines and a method of treatment.
Type:
Grant
Filed:
December 6, 1993
Date of Patent:
October 14, 1997
Assignee:
Stichting Centraal Diergeneeskundig Instituut
Inventors:
Franciscus Antonius Maria Rijsewijk, Johannes Theodorus van Oirschot, Roger Kamiel Maes
Abstract: Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising a Lelystad Agent-specific nucleotide sequence. Peptides comprising a Lelystad Agent-specific amino acid sequence. Lelystad Agent-specific antibodies.
Type:
Grant
Filed:
November 26, 1993
Date of Patent:
April 15, 1997
Assignee:
Stichting Centraal Diergeneeskundig Instituut
Inventors:
Gert Wensvoort, Catharinus Terpstra, Joannes M. A. Pol
Abstract: A method of detecting or determining a sequence of amino acids which is antigenically active within a known amino acid sequence of a protein or portion thereof comprises the steps of: synthesising a plurality of peptides, each of said peptides comprising a sequence of a plurality of amino acids which corresponds to a sequence within the known amino acid sequence, and the said peptides having overlapping amino acid sequences; contacting each of said peptides with antibody against the protein or portion of interest; and detecting or determining the presence or absence of an antigen-antibody reaction between each of said peptides and said antibody to indicate whether or not said peptide has antigenic activity.
Type:
Grant
Filed:
June 1, 1994
Date of Patent:
January 21, 1997
Assignees:
Chiron Mimotopes Pty. Ltd, Stichting Centraal Diergeneeskundig Instituut