Abstract: The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound in a solvent. The macromolecule can be incorporated in the vesicles and/or bound to the vesicles or another aggregate of the new compounds. In a preferred embodiment at least one targeting molecule, for instance a (labelled) antibody, may further be attached to the vesicles.
Type:
Grant
Filed:
July 24, 1996
Date of Patent:
December 29, 1998
Assignees:
Stitching Voor DeTechnische Wetenschappen, Rijksuniversiteit Groningen, Stichting Scheikundig Ondoerzoek in Nederland
Inventors:
Jan Bernard Frederik Nicolaas Engberts, Anno Wagenaar, Dirk Hoekstra, Irene Van Der Woude, Marcel Herman Jozef Ruiters