Patents Assigned to Stichting VU
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Patent number: 11963663Abstract: A fibre endoscope system (100) comprises a catheter (10) with a probe head (10a) for entering into a body cavity (C) adjacent or near a sample region (S). A source fiber (11) has a first fiber ending (11a) and a signal fiber (12) has a second fiber ending (12a) both remote from the probe head (10a) but separate. A sampling fiber (13) has a third fiber ending (13a) disposed at the probe head (10a). A fiber coupler (15) is configured to optically couple at least the source fiber (11) to the sampling fiber (13), and the sampling fiber (13) to the signal fiber (12). A sampling fiber length (L13) of the sampling fiber (13) between a fiber coupler (15) and the third fiber ending (13a) is shorter than a source fiber length (L11) of the source fiber (11) between the fiber coupler (15) and the first fiber ending (11a).Type: GrantFiled: March 28, 2019Date of Patent: April 23, 2024Assignee: Stichting VUInventors: Fabio Feroldi, Johannes Fitzgerald De Boer
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Patent number: 11944701Abstract: The invention relates to the use of sphingosine-based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine-based compounds. Compositions comprising sphingosine-based compounds are also provided.Type: GrantFiled: February 3, 2022Date of Patent: April 2, 2024Assignee: STICHTING VUInventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van 'T Hof
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Patent number: 11788081Abstract: The present invention relates to methods and cross-linkers for the macrocyclization of proteins. The invention is useful for increasing the stability of a protein.Type: GrantFiled: April 18, 2019Date of Patent: October 17, 2023Assignee: Stichting VUInventors: Tom Norbert Grossmann, Marta Pelay Gimeno, Sven Hennig, Saskia Antonie Neubacher
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Patent number: 11273113Abstract: The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.Type: GrantFiled: April 26, 2013Date of Patent: March 15, 2022Assignee: STICHTING VUInventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van 'T Hof
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Patent number: 11267694Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to said support structure; and, a proof mass flexibly suspended by said suspension springs; wherein at least one of said suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.Type: GrantFiled: July 14, 2020Date of Patent: March 8, 2022Assignees: STICHTING VU-VUMC, FOM-NIKHEFInventors: Eric Hennes, Alessandro Bertolini, Johannes Franciscus Van Den Brand
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Publication number: 20210080394Abstract: One aspect of this disclosure relates to a method for determining a presence of at least one guest structure at a host structure. The method comprises a light-sensitive system receiving light from the host structure. The host structure hosts one or more optically active entities at at least one part of the host structure. Herein, the at least one part does not host the at least one guest structure. Furthermore, the optically active entities cause light emission from said at least one part. The method also comprises the light-sensitive system outputting a signal based on the received light. The method further comprises determining a light value based on the output signal. The light value indicates an amount of light from the host structure being incident on the light-sensitive system. The method also comprises determining on the basis of the light value at least one of a quantity and a position of the at least one guest structure at the host structure.Type: ApplicationFiled: February 5, 2019Publication date: March 18, 2021Applicants: LUMICKS TECHNOLOGIES B.V., STICHTING VUInventors: Iddo Heller, Anna Elisabeth Christina MEIJERING, Gijs Jan Lodewijk WUITE, Erwin Johannes Gerard PETERMAN, Andreas Sebastian BIEBRICHER
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Publication number: 20210022590Abstract: A fibre endoscope system (100) comprises a catheter (10) with a probe head (10a) for entering into a body cavity (C) adjacent or near a sample region (S). A source fiber (11) has a first fiber ending (11a) and a signal fiber (12) has a second fiber ending (12a) both remote from the probe head (10a) but separate. A sampling fiber (13) has a third fiber ending (13a) disposed at the probe head (10a). A fiber coupler (15) is configured to optically couple at least the source fiber (11) to the sampling fiber (13), and the sampling fiber (13) to the signal fiber (12). A sampling fiber length (L13) of the sampling fiber (13) between a fiber coupler (15) and the third fiber ending (13a) is shorter than a source fiber length (L11) of the source fiber (11) between the fiber coupler (15) and the first fiber ending (11a).Type: ApplicationFiled: March 28, 2019Publication date: January 28, 2021Applicant: Stichting VUInventors: Fabio FEROLDI, Johannes Fitzgerald DE BOER
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Publication number: 20210000367Abstract: A first aspect provides, in a device for processing biomedical data obtained from a body, a method of determining brain activity. The method comprises obtaining neuron oscillation signal data of a first part of a brain over a period of time. The oscillation signal data is apportioned in timeslots within the period and per time slot, based on the oscillation data for the timeslot, an amplitude value and variation value representing data values in the timeslot are obtained. A correlation value is determined between the amplitude values and the corresponding variation values over at least a substantial part of the first time period; and the correlation value is provided as an output. The correlation value may optionally be used for estimating a ratio between excitation and inhibition activity of the brain under scrutiny.Type: ApplicationFiled: March 18, 2019Publication date: January 7, 2021Applicant: Stichting VUInventors: Klaus LINKENKAER-HANSEN, Richard Edward HARDSTONE
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Publication number: 20200399688Abstract: A method for supercoiling DNA, e.g. negatively supercoiling DNA, is disclosed. In an initial state, at least part of a DNA molecule is torsionally constrained and associated with a first linking number. The at least part of the DNA molecule has a first end connected to a first body and a second end connected to a second body. The method comprises increasing a distance between the first body and the second body for inducing a torque in the at least part of the DNA molecule and for bringing the at least part of the DNA molecule from the initial state into an intermediate state. In the intermediate state the at least part of the DNA molecule is temporarily torsionally unconstrained for at least partially releasing the induced torque for changing, e.g. decreasing, the first linking number.Type: ApplicationFiled: January 7, 2019Publication date: December 24, 2020Applicant: STICHTING VUInventors: Graeme Alan KING, Federica BURLA, Gijs Jan Lodewijk WUITE, Erwin Johannes Gerard PETERMAN
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Publication number: 20200370974Abstract: One aspect of this disclosure relates to a computer-implemented method for determining a force acting on at least part of a structure, for example a biological structure, such as a DNA molecule. The method comprises controlling a light-sensitive system, e.g. of a microscope, to determine light information based on light from the structure. The light is incident on at least a part of the light sensitive system. The light-sensitive system may be said to capture the light from the structure. The at least part of the structure comprises one or more optically active entities, such as DNA intercalator molecules and donor/acceptor fluorophores. At least one of (i) an optical activity of the entities and (ii) a quantity of the entities depends on the force acting on the at least part of the structure. Furthermore, the light information defines a light property value associated with said at least part of the structure.Type: ApplicationFiled: November 19, 2018Publication date: November 26, 2020Applicant: STICHTING VUInventors: Graeme Alan KING, Andreas Sebastian BIEBRICHER, Iddo HELLER, Erwin Johannes Gerard PETERMAN, Gijs Jan Lodewijk WUITE
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Publication number: 20200232931Abstract: A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.Type: ApplicationFiled: January 23, 2020Publication date: July 23, 2020Applicants: ASML Netherlands B.V., Stiching Nederlandse Wetenschappelijk Onderzoek Instituten, Stichting VU, Universiteit van AmsterdamInventors: Stefan Michiel WITTE, Gijsbert Simon Matthijs JANSEN, Lars Christian FREISEM, Kjeld Sijbrand Eduard EIKEMA, Simon Gijsbert Josephus MATHIJSSEN
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Patent number: 10710870Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to the support structure; and, a proof mass flexibly suspended by the suspension springs; wherein at least one of the suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.Type: GrantFiled: December 6, 2016Date of Patent: July 14, 2020Assignees: STICHTING VU-VUMC, FOM-NIKHEFInventors: Eric Hennes, Alessandro Bertolini, Johannes Franciscus Van Den Brand
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Patent number: 10660068Abstract: A method for managing communication in a wireless mesh network comprising a plurality of wireless nodes and a wireless node for use in such network are described, wherein said method may comprise: providing a time slot schedule (frame), preferably a TDMA time slot schedule (frame), comprising one or more time slots, including a transmission time slot enabling a node to transmit a broadcast message, a reception time slot enabling a node to receive a broadcast message from one or more other nodes; and/or a sleep time slot for configuring said node in an idle state; and, assigning said time slots to nodes in said network on the basis of the position of said nodes in said network.Type: GrantFiled: June 6, 2014Date of Patent: May 19, 2020Assignees: STICHTING VU-VUMC, FOM-NIKHEFInventors: Henk Jan Bulten, Johannes Franciscus Josephina Van Den Brand
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Publication number: 20200041563Abstract: Disclosed is a method for obtaining a computationally determined interference electric field describing scattering of radiation by a pair of structures comprising a first structure and a second structure on a substrate. The method comprises determining a first electric field relating to first radiation scattered by the first structure; determining a second electric field relating to second radiation scattered by the second structure; and computationally determining the interference of the first electric field and second electric field, to obtain a computationally determined interference electric field.Type: ApplicationFiled: July 31, 2019Publication date: February 6, 2020Applicant: Stichting VUInventors: Patricius Aloysius Jacobus TINNEMANS, Patrick WARNAAR, Vasco Tomas Tenner, Maurits Van der schaar
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Publication number: 20190310559Abstract: Methods and apparatus are disclosed for determining a characteristic of a structure. In one arrangement, the structure is illuminated with first illumination radiation to generate first scattered radiation. A first interference pattern is formed by interference between a portion of the first scattered radiation reaching a sensor and first reference radiation. The structure is also illuminated with second illumination radiation from a different direction. A second interference pattern is formed using second reference radiation. The first and second interference patterns are used to determine the characteristic of the structure. Azimuthal angles of the first and second reference radiations onto the sensor are different.Type: ApplicationFiled: April 5, 2019Publication date: October 10, 2019Applicants: Stichting VU, Stichting Nederlandse Wetenschappelijk Onderzoek Instituten, Universiteit van Amsterdam, ASML Netherlands B.V.Inventors: Johannes Fitzgerald DE BOER, Vasco Tomas TENNER, Arie Jeffrey DEN BOEF, Christos MESSINIS
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Publication number: 20190265028Abstract: Disclosed is a method and associated apparatus for measuring a characteristic of interest relating to a structure on a substrate. The method comprises calculating a value for the characteristic of interest directly from the effect of the characteristic of interest on at least the phase of illuminating radiation when scattered by the structure, subsequent to illuminating said structure with said illuminating radiation.Type: ApplicationFiled: February 15, 2019Publication date: August 29, 2019Applicants: Stichting VU, Stichting Nederlandse Wetenschappelijk Onderzoek Instituten, Universiteit van Amsterdam, ASML Netherlands B.V.Inventors: Patricius Aloysius Jacobus TINNEMANS, Vasco Tomas Tenner, Arie Jeffrey Den Boef, Hugo Augustinus Joseph Cramer, Patrick Warnaar, Grzegorz Grzela, Martin Jacobus Johan Jak
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Publication number: 20190107781Abstract: Described is a metrology system for determining a characteristic of interest relating to at least one structure on a substrate, and associated method. The metrology system comprises a processor being configured to computationally determine phase and amplitude information from a detected characteristic of scattered radiation having been reflected or scattered by the at least one structure as a result of illumination of said at least one structure with illumination radiation in a measurement acquisition, and use the determined phase and amplitude to determine the characteristic of interest.Type: ApplicationFiled: October 3, 2018Publication date: April 11, 2019Applicants: Stichting VU, Stichting Nederlandse Wetenschappelijk Onderzoek Instituten, Universiteit van Amsterdam, ASML Netherlands B.V.Inventors: Patricius Aloysius Jacobus TINNEMANS, Arie Jeffrey Den Boef, Armand Eugene Albert Koolen, Nitesh Pandey, Vasco Tomas Tenner, Willem Marie Julia Marcel Coene, Patrick Warnaar
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Patent number: 10174365Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analyzing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.Type: GrantFiled: January 16, 2012Date of Patent: January 8, 2019Assignees: STICHTING VU-VUMC, VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORGInventors: Thomas Wurdinger, Rolf Jonas Nilsson
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Patent number: 10174364Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analyzing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.Type: GrantFiled: July 15, 2011Date of Patent: January 8, 2019Assignee: STICHTING VU-VUmcInventors: Thomas Würdinger, Rolf Jonas Nilsson
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Publication number: 20180348145Abstract: A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.Type: ApplicationFiled: May 15, 2018Publication date: December 6, 2018Applicants: ASML Netherlands B.V., Stichting Nederlandse Wetenschappelijk Onderzoek Instituten, Stichting VU, Universiteit van AmsterdamInventors: Stefan Michiel WITTE, Gijsbert Simon Matthijs Jansen, Lars Christian Freisem, Kjeld Sijbrand Eduard Eikema, Simon Gijsbert Josephus Mathijssen