Patents Assigned to Stichting VU-VUmc
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Patent number: 11267694Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to said support structure; and, a proof mass flexibly suspended by said suspension springs; wherein at least one of said suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.Type: GrantFiled: July 14, 2020Date of Patent: March 8, 2022Assignees: STICHTING VU-VUMC, FOM-NIKHEFInventors: Eric Hennes, Alessandro Bertolini, Johannes Franciscus Van Den Brand
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Patent number: 10710870Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to the support structure; and, a proof mass flexibly suspended by the suspension springs; wherein at least one of the suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.Type: GrantFiled: December 6, 2016Date of Patent: July 14, 2020Assignees: STICHTING VU-VUMC, FOM-NIKHEFInventors: Eric Hennes, Alessandro Bertolini, Johannes Franciscus Van Den Brand
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Patent number: 10660068Abstract: A method for managing communication in a wireless mesh network comprising a plurality of wireless nodes and a wireless node for use in such network are described, wherein said method may comprise: providing a time slot schedule (frame), preferably a TDMA time slot schedule (frame), comprising one or more time slots, including a transmission time slot enabling a node to transmit a broadcast message, a reception time slot enabling a node to receive a broadcast message from one or more other nodes; and/or a sleep time slot for configuring said node in an idle state; and, assigning said time slots to nodes in said network on the basis of the position of said nodes in said network.Type: GrantFiled: June 6, 2014Date of Patent: May 19, 2020Assignees: STICHTING VU-VUMC, FOM-NIKHEFInventors: Henk Jan Bulten, Johannes Franciscus Josephina Van Den Brand
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Patent number: 10174365Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analyzing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.Type: GrantFiled: January 16, 2012Date of Patent: January 8, 2019Assignees: STICHTING VU-VUMC, VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORGInventors: Thomas Wurdinger, Rolf Jonas Nilsson
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Patent number: 10174364Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analyzing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.Type: GrantFiled: July 15, 2011Date of Patent: January 8, 2019Assignee: STICHTING VU-VUmcInventors: Thomas Würdinger, Rolf Jonas Nilsson
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Patent number: 10058324Abstract: A suture device includes a needle operating device movable longitudinally with respect to a housing between at least an insertion position and a needle transfer position. The needle operating device includes an elongate operating element arranged extending from a distal end of the housing to or near a housing proximal end. A needle holder connected at a distal end of the operating element holds two or more needles, with free ends directed in proximal direction. The holder is movable with respect to a protection device between at least a protecting position shielding the free ends, and a non-protecting position for the same. A needle receive device at a distal end of the housing receives the free ends when the operating device is moved to the transfer position. In at least the insertion position the holder and the protection device are spaced longitudinally from the housing to receive a tissue therebetween.Type: GrantFiled: November 16, 2012Date of Patent: August 28, 2018Assignee: STICHTING VU-VUMCInventors: Rianne Irene Van Loenen, Micha Ilan Paalman, Alexander Arnold Frederik Adriaan Veenhof
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Publication number: 20170322215Abstract: The present invention relates to the fields of medicine and molecular diagnostics. In particular, it relates to a novel method for the treatment, prevention and/or delay of cancer and to a diagnostic method involving detection of a novel auto-active and intracellular mutant of MET.Type: ApplicationFiled: November 18, 2015Publication date: November 9, 2017Applicants: Stichting Katholieke Universiteit, Stichting VU-VumcInventors: Anna Catharina Navis, Wilhelmus Petrus Johannes Leenders, Thomas Würdinger
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Patent number: 9766180Abstract: The present disclosure concerns a method and system for imaging a molecular strand (MS). The method comprises providing a sample volume (SV) comprising the strand (MS); providing an excitation beam (EB) having an excitation focus (EF) in the sample volume (SV); scanning the excitation focus (EF) in the sample volume (SV) along a one dimensional scanning line (SL); trapping an end of the strand (MS) in the sample volume (SV) and extending the strand (MS) along a one-dimensional trapping line (LL) parallel to the scanning line (SL); aligning the trapping line (LL) to coincide with the scanning line (SL) to have the scanning excitation focus (EF) coincide with the strand (MS); and recording the fluorescence response (FR) as a function of a plurality of distinct scanning positions (X0) of the excitation focus (EF) along the scanning line (SL).Type: GrantFiled: June 2, 2014Date of Patent: September 19, 2017Assignee: Stichting VU-VUmcInventors: Gijs Jan Lodewijk Wuite, Erwin Johannes Gerard Peterman, Iddo Heller, Gerrit Sitters, Andrea Candelli, Stefan Walter Hell
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Publication number: 20170199196Abstract: The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individual is at risk of suffering from or is suffering from colorectal cancer. The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.Type: ApplicationFiled: February 28, 2017Publication date: July 13, 2017Applicant: STICHTING VU-VUMCInventors: Linda Janna Willemien Bosch, Meike De Wit, Beatriz Pinto Pinto Morais De Carvalho, Remond Johannes Adriaan Fijneman, Gerrit Albert Meijer, Cornelia Ramona Jimenez, Sander Rogier Piersma, Viet Thang Pham, Gideon Oudgenoeg
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Publication number: 20170130277Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.Type: ApplicationFiled: June 19, 2015Publication date: May 11, 2017Applicants: STICHTING VU-VUMC, INTERNA TECHNOLOGIES B.V.Inventors: Gerrit Albert MEIJER, Begoña DIOSDADO, Lisette M. TIMMER, Edwin Pieter Johan Gerard CUPPEN, Eugene BEREZIKOV, Francesco CERISOLI, Roeland Quirinus Jozef SCHAAPVELD
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Patent number: 9331844Abstract: Distribution of reference frequency and timing information in a network involves determining latency between a first and second node from time delay between transmission of a reference frequency and timing signal and reception of an optical return timing signal in response. In a network with pairs of first and second optical fibers in optical fiber connections between network nodes, for transmission of optical data signals separately in mutually opposite directions between the network nodes respectively, provisions are made to transmit the reference frequency and timing signal and the resulting optical return signal via the same fiber, one in the same direction as the unidirectional data signal over that fiber and the other upstream. Repeaters between the nodes may be modified to pass such signals upstream and downstream.Type: GrantFiled: May 24, 2012Date of Patent: May 3, 2016Assignee: STICHTING VU-VUMCInventors: Roeland Johannus Marie Wilhelm Nuijts, Jeroen Cornelis Jean Koelemeij
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Publication number: 20150147361Abstract: The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.Type: ApplicationFiled: April 26, 2013Publication date: May 28, 2015Applicant: Stichting VU-VUmcInventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van'T Hof
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Publication number: 20140271463Abstract: The disclosure relates to the use of altered BRI2 levels as a biomarker for the risk of developing Alzheimer's disease. Novel treatments based on altered BRI2 levels and anti-BRI2 antibodies are also provided.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: Stichting VU-VUmcInventors: Marta DEL CAMPO MILAN, Cornelia Ramona Jimenez, Chrlott Elisabeth Teunissen
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Publication number: 20140199693Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.Type: ApplicationFiled: January 16, 2012Publication date: July 17, 2014Applicant: STICHTING VU-VUMCInventors: Thomas Wurdinger, Rolf Jonas Nilsson
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Publication number: 20140154182Abstract: The invention is directed to a N,N-substituted guanidine compound or a salt or solvate thereof according to formula (1), R1RNC(NH)NR2R3, wherein R1 is methyl and R2 is hydrogen. R3 is a organic group comprising a halogen and thiomethyl substituted phenyl group. R is an organic group comprising a substituted aryl group Z wherein the substituent group is —Y—R4, wherein Y is a heteroatom chosen from the group consisting of O, S and N and R4 is a fluorinated organic group.Type: ApplicationFiled: May 30, 2012Publication date: June 5, 2014Applicant: STICHTING VU-VUMCInventors: Pieter Jacob Klein, Athansios Metaxas, Albert Dirk Windhorst, Johannes Antonius Maria Christiaans, Bart Nicolaas Maria van Berckel
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Publication number: 20140135604Abstract: The invention relates to a system for predicting the viability of a body tissue in a patient. The system comprises a computing device, and a first pressure measuring device for measuring local perfusion pressure in the body tissue of the patient. This measuring device is connected to the computing device. A second pressure measuring device is provided for measuring the systemic perfusion pressure of the patient, said second pressure measuring device being connected to the computing device. A feedback indicator is connected to the computing device and is adapted to indicate the viability of the tissue calculated by the computing device on the basis of the measured local and systemic perfusion pressures. The invention also includes a method of predicting the viability of the body tissue and to the first pressure measuring device.Type: ApplicationFiled: July 4, 2012Publication date: May 15, 2014Applicants: Veenhof Medical Devices B.V., STICHTING VU-VUMCInventors: Miguel Angel Cuesta Valentin, Alexander Amold Frederik Adriaan Veenhof
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Patent number: 8580528Abstract: The invention relates to methods for predicting a clinical response to B-lymphocyte inhibiting or depleting therapies (BCIDT) using expression levels of genes of the Type I INF pathway. In another aspect, the invention relates to a method for evaluating a pharmacological effect of a treatment with B-lymphocyte inhibiting or depleting therapy.Type: GrantFiled: October 15, 2010Date of Patent: November 12, 2013Assignee: Stichting VU-VUMCInventors: Cornelis Lammert Verweij, Paul-Peter Tak
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Publication number: 20130196873Abstract: The present invention relates to a method of analyzing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.Type: ApplicationFiled: July 15, 2011Publication date: August 1, 2013Applicant: STICHTING VU-VUmcInventors: Thomas Würdinger, Rolf Jonas Nilsson
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Publication number: 20120167246Abstract: The present invention relates generally to the field of plant molecular biology and agents useful in the manipulation of plant physiological and biochemical properties. More particularly, the present invention provides genetic and proteinaceous agents capable of modulating or altering the level of acidity or alkalinity in a cell, group of cells, organelle, part or reproductive portion of a plant. Genetically altered plants, plant parts, progeny, subsequent generations and reproductive material including flowers or flowering parts having cells exhibiting an altered cellular including vacuolar pH compared to a non-genetically altered plant are also provided.Type: ApplicationFiled: April 30, 2010Publication date: June 28, 2012Applicants: Stichting VU-VUmc, STICHTING VOOR DE TECHNISCHE WETENSCHAPInventors: Francesca Quattrocchio, Ronald Koes, Kees Spelt