Abstract: A method of treating a subject in need thereof, is carried out by (a) administering said subject a therapeutic intervention (e.g., an active agent) in a treatment effective amount; and concurrently (b) administering said subject caloric vestibular stimulation in a treatment effective amount, said caloric vestibular stimulation administered so as to enhance the efficacy of said active agent. In some embodiments, the caloric vestibular stimulation is administered as an actively controlled time varying waveform.

Abstract: A clipper for clipping nails of an animal such as a dog, or cat, that allows for the clipping of an individual nail at the desired length while preventing injury to the animal, including a clipper portion and a sensing portion which allows the nail to be localized in a desired position relative to the clipping plane of the clipper and the internal structure of the nail, wherein the sensing portion is included within circuitry that includes a signal generation portion, a signal reception portion, and a quick indicator. The animal nail is positioned near the clipper portion and the sensing portion produces a sensible signal confirming the position of the clipping plane upon the nail, particularly the quick of the nail. The user then may adjust the position of the clipper portion such that the clipping plane avoids the quick. The user then actuates the clipper portion and trims the nail.