Abstract: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.
Type:
Grant
Filed:
April 8, 2010
Date of Patent:
April 23, 2013
Assignees:
SpiderTech, a Division of Stoecker & Associates, a Subsidiary of The Dermatology Center, LLC., The Regents of the University of Michigan, Office of Technology Transfer, The Curators of the University of Missouri, University Hall, The United States of America as Represented by the Secretary of the Air Force, Directorate of Intellectual Property Law
Inventors:
William V. Stoecker, Hernan F. Gomez, Jonathan A. Green, David L. McGlasson
Abstract: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.
Type:
Application
Filed:
April 8, 2010
Publication date:
August 5, 2010
Applicants:
SPIDERTECH, A DIVISION OF STOECKER & ASSOCIATES, A SUBSIDIARY OF THE DERMATOLOGY CENTER, LLC, THE CURATORS OF THE UNIVERSITY OF MISSOURI, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors:
William V. Stoecker, Hernan F. Gomez, Jonathan A. Green, David L. McGlasson
Abstract: Improved methods for computer-aided analysis of identifying features of skin lesions from digital images of the lesions are provided. Improved preprocessing of the image that 1) eliminates artifacts that occlude or distort skin lesion features and 2) identifies groups of pixels within the skin lesion that represent features and/or facilitate the quantification of features are provided including improved digital hair removal algorithms. Improved methods for analyzing lesion features are also provided.
Type:
Grant
Filed:
May 30, 2006
Date of Patent:
March 30, 2010
Assignees:
Stoecker & Associates, a subsidiary of The Dermatology Center, LLC, The Curators of the University of Missouri
Inventors:
William V. Stoecker, Randy H. Moss, R. Joe Stanley, Xiaohe Chen, Kapil Gupta, Bijaya Shrestha, Pavani Jella
Abstract: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.
Type:
Application
Filed:
October 17, 2006
Publication date:
June 21, 2007
Applicants:
SpiderTech, a division of Stoecker & Associates, a Subsidiary of The Dermatology Center, LLC, The Curators of the University of Missouri, The United States of America as represented by the Secretary of the Air Force
Inventors:
William Stoecker, Hernan Gomez, Jonathan Green, David McGlasson
Abstract: Improved methods for computer-aided analysis of identifying features of skin lesions from digital images of the lesions are provided. Improved preprocessing of the image that 1) eliminates artifacts that occlude or distort skin lesion features and 2) identifies groups of pixels within the skin lesion that represent features and/or facilitate the quantification of features are provided including improved digital hair removal algorithms. Improved methods for analyzing lesion features are also provided.
Type:
Application
Filed:
May 30, 2006
Publication date:
November 30, 2006
Applicant:
Stoecker & Associates, a Subsidiary of The Dermatology Center, LLC
Inventors:
William Stoecker, Randy Moss, R. Stanley, Xiaohe Chen, Kapil Gupta, Ravirala Narayana, Bijaya Shrestha, Pavani Jella