Abstract: Adhesive patches for the transdermal administration of granisetron, comprise an acrylic adhesive containing non-acidic nucleophilic moieties which substantially increase flux of granisetron across the skin.
Type:
Grant
Filed:
February 5, 2004
Date of Patent:
October 27, 2009
Assignee:
Strakan International Limited
Inventors:
Peter Altenschöpfer, Adam Charles Watkinson
Abstract: Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (½ to 1/20) of those known to induce vasodilation in “normal” circulations.
Type:
Grant
Filed:
June 11, 2003
Date of Patent:
July 1, 2008
Assignee:
Strakan International Limited
Inventors:
Jeremy P. W. Heaton, Michael A. Adams, James D. Banting