Abstract: The present disclosure relates to an isolated polynucleotide comprising a sequence that encodes an interleukin (IL)-12 molecule, and a delivery system that can carry the polynucleotides. The disclosure also includes methods of making the polynucleotides and methods of treatment using the same.
Type:
Application
Filed:
January 10, 2022
Publication date:
May 23, 2024
Applicant:
STRAND THERAPEUTICS INC.
Inventors:
Tasuku KITADA, Jacob BECRAFT, Ryan SOWELL, Jaspreet KHURANA, Anna SIMON, Joseph BARBERIO, Weiyu ZHAO, Alexander LEMAIRE, Aalok SHAH
Abstract: The present disclosure relates to a lipid nanoparticle comprising (i) one or more types of lipid; and (ii) a modified mRNA comprising a sequence that encodes an interleukin (IL)-12 molecule, wherein the lipid nanoparticle is capable of triggering immunogenic cell death, and methods of treatment using the same
Type:
Application
Filed:
July 26, 2021
Publication date:
September 21, 2023
Applicant:
STRAND THERAPEUTICS INC.
Inventors:
Jacob BECRAFT, Ryan SOWELL, Jaspreet KHURANA, Tasuku KITADA