Abstract: Methods and compositions comprising isolated nucleic acid molecules specific to Neisseria meningitidis, Candida glabrata and Aspergillus fumigatus heat shock proteins (Hsps), as well as vector constructs and isolated polypeptides specific to the same are provided. Such compositions and methods are useful for the diagnosis of infections by these organisms and for generating an immune response to the organisms.
Type:
Application
Filed:
October 11, 2002
Publication date:
May 29, 2003
Applicant:
Stressgen Biotechnologies Corporation, a Victoria, Canada corporation
Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.
Type:
Application
Filed:
October 9, 2002
Publication date:
March 13, 2003
Applicant:
Stressgen Biotechnologies Corporation, a Victoria, Canada corporation
Inventors:
Marvin Siegel, N. Randall Chu, Lee A. Mizzen