Abstract: A process and a pharmaceutical formulation of a water insoluble drug encapsulated in a soft gelatin capsule. The formulation preferably has loratadine as the active ingredient which is formed into a blend with a vehicle which includes a solubilizer, a emulsifier and optionally a viscosity modifying agent. Preferably, the gel encapsulated blend provides a self emulsifying drug delivery system for oral administration of the pharmaceutical formulation.

Abstract: An oily wax matrix suspension pharmaceutical formulation is prepared for oral administration of an active ingredient, such as ibuprofen, through a soft gelatin capsule drug delivery device. The ibuprofen may be in free acid or a mixture of free acid and ibuprofen alkali salt form. The active pharmaceutical ingredient is embedded in an oily wax matrix which is preferably blended with a surfactant. A preferred surfactant is lecithin, a preferred suspending agent is yellow beeswax, and a preferred suspension medium is soybean oil which are all natural ingredients.

Abstract: A one pot process for the preparation of sterically hindered triaryl phosphite is provided. It is suitable for large scale commercial production with an advantage of having carried out the reaction at 0-5° C. in a shortest time of 1 hr using pyridine as Lewis base to remove HCl formed in the reaction; thus avoiding the usage of scrubber. The triaryl phosphite is of the formula P(OR)3 and is produced by reacting a di alkyl—substituted phenol of formula ROH with phosphorus trihalide in a presence of a Lewis base, wherein R represents an aryl compound of a formula C6H3RaRb, wherein Ra is tertiary alkyl, Rb is lower alkyl or tertiary alkyl. The process preferably comprises of mixing a stoichiometric amount of 2,4-dialkyl phenol with phosphorous trihalide in methylene chloride with different stoichiometric amounts of pyridine such as the molar equivalent, 10 mol %, 20 mol % and 50 mol % more than the amount of 2,4 dialkyl phenol. The reaction is preferably carried out at 0-5° C.

Abstract: A one pot process for the preparation of sterically hindered triaryl phosphite is provided. The triaryl phosphite is of the formula P(OR)3 and is produced by reacting a hydroxyl-substituted aryl compound of formula ROH with phosphorus trihalide in a presence of a Lewis base, wherein R represents an aryl compound of a formula C6H3R1R2, wherein each R1 and R2 is an organic substituent. The process preferably comprises of mixing a substantial stoichiometric amount of 2,4-dialkyl phenol with phosphorous trihalide in methylene chloride with stoichiometric amount of pyridine. The reaction is preferably carried out at 0-5° C. and takes only 1 hr for the completion, followed by a precipitation out of isopropanol.