Abstract: The present invention relates to a pharmaceutical formulation for oral administration through a soft gelatin capsule drug delivery device, wherein the pharmaceutical formulation has Pseudoephedrine HCl as the active pharmaceutical ingredient. The active pharmaceutical ingredient is embedded into an oily matrix, also the formulation comprises viscosity imparting agents, a surfactant; a suspending agent; and a suspension medium. The viscosity-imparting agents are partially hydrogenated vegetable oil and colloidal silicon dioxide, the surfactant is lecithin, the suspending agent is yellow beeswax, and the suspension medium is soybean oil. In one preferred embodiment, the formulation consists essentially of about 60 mg by weight of Pseudoephedrine HCl, about 15-25 mg by weight of partially hydrogenated vegetable oil, about 10-20 mg by weight of yellow beeswax, about 2-8 mg by weight of lecithin, about 2-8 mg by weight of silicon dioxide; and about 150-250 mg by weight of soybean oil.

Abstract: A process and a pharmaceutical formulation of a water insoluble drug encapsulated in a soft gelatin capsule. The formulation preferably has loratadine as the active ingredient which is formed into a blend with a vehicle which includes a solubilizer, a emulsifier and optionally a viscosity modifying agent. Preferably, the gel encapsulated blend provides a self emulsifying drug delivery system for oral administration of the pharmaceutical formulation.

Abstract: An oily wax matrix suspension pharmaceutical formulation is prepared for oral administration of an active ingredient, such as ibuprofen, through a soft gelatin capsule drug delivery device. The ibuprofen may be in free acid or a mixture of free acid and ibuprofen alkali salt form. The active pharmaceutical ingredient is embedded in an oily wax matrix which is preferably blended with a surfactant. A preferred surfactant is lecithin, a preferred suspending agent is yellow beeswax, and a preferred suspension medium is soybean oil which are all natural ingredients.

Abstract: A one pot process for the preparation of sterically hindered triaryl phosphite is provided. It is suitable for large scale commercial production with an advantage of having carried out the reaction at 0-5° C. in a shortest time of 1 hr using pyridine as Lewis base to remove HCl formed in the reaction; thus avoiding the usage of scrubber. The triaryl phosphite is of the formula P(OR)3 and is produced by reacting a di alkyl—substituted phenol of formula ROH with phosphorus trihalide in a presence of a Lewis base, wherein R represents an aryl compound of a formula C6H3RaRb, wherein Ra is tertiary alkyl, Rb is lower alkyl or tertiary alkyl. The process preferably comprises of mixing a stoichiometric amount of 2,4-dialkyl phenol with phosphorous trihalide in methylene chloride with different stoichiometric amounts of pyridine such as the molar equivalent, 10 mol %, 20 mol % and 50 mol % more than the amount of 2,4 dialkyl phenol. The reaction is preferably carried out at 0-5° C.

Abstract: A one pot process for the preparation of sterically hindered triaryl phosphite is provided. The triaryl phosphite is of the formula P(OR)3 and is produced by reacting a hydroxyl-substituted aryl compound of formula ROH with phosphorus trihalide in a presence of a Lewis base, wherein R represents an aryl compound of a formula C6H3R1R2, wherein each R1 and R2 is an organic substituent. The process preferably comprises of mixing a substantial stoichiometric amount of 2,4-dialkyl phenol with phosphorous trihalide in methylene chloride with stoichiometric amount of pyridine. The reaction is preferably carried out at 0-5° C. and takes only 1 hr for the completion, followed by a precipitation out of isopropanol.

Abstract: Footwear comprising a sole, an upper, and a lace-binding system comprising a plurality of replaceable eyelet extenders. Replacing eyelet extenders, or components thereof, with others of a different color facilitates switching footwear from one color pattern to another. Replacing eyelet extenders, or components thereof, with others of a different length, flexibility, or elasticity facilitates modifying flexibility between eyelets and lace.

Abstract: Footwear with single or double vamp sections comprising a split tongue including a rearward tongue portion which is firmly attached along one side thereof to a medial vamp section of the shoe. While the rearward tongue portion is firmly connected to a medial vamp section, the connection may be permanent or replaceable. A forward tongue portion may be integrally formed with the forward upper, or be an extension of the forward upper, or be secured to the forward upper along a transverse edge and/or to one or both of the vamp sections, or be secured to one of the vamp sections only. One or both tongue portions may be formed to have pockets for receiving cushioning members and/or saddle members to reduce pressure on the instep. The forward edge of the rearward tongue portion overlies the rearward edge of the forward tongue portion in the working position.

Abstract: A footwear saddle and method for dissipating pressure between footwear and the wearer's foot. The saddle comprises a member having a bridge offset from a central axis of the member which overlays the instep of the wearer's foot. During usage, the pressure between the footwear and the foot is dissipated by the saddle, the bridge maintaining the gap between the instep of the foot and the saddle.