Abstract: The invention is directed to a method for the prophylaxis or treatment of an animal for deleterious physiological effects such as systemic hypotension caused by nitric oxide production induced by a biological response modifier. Examples of such biological response modifiers include but are not limited to a cytokine and an endotoxin. The invention is also directed to a method for the treatment of septic shock.
Type:
Grant
Filed:
February 19, 1992
Date of Patent:
March 22, 1994
Assignees:
Board of Regents, The University of Texas System, Strohtech, Inc., Duke University
Inventors:
Robert G. Kilbourn, Joseph De Angelo, Joseph Bonaventura