Abstract: A fluorescence imaging system for imaging an object, the system includes a white light provider that emits white light, an excitation light provider that emits excitation light in a plurality of excitation wavebands for causing the object to emit fluorescent light, a component that directs the white light and excitation light to the object and collects reflected white light and emitted fluorescent light from the object, a filter that blocks light in the excitation wavebands and transmits at least a portion of the reflected white light and fluorescent light, and an image sensor assembly that receives the transmitted reflected white light and the fluorescent light.

Abstract: An imaging device having an imaging field of view, the imaging device including at least one illumination port configured to output light for illuminating a target; an imaging sensor to detect light traveling along an optical path to the imaging sensor; and a first movable window positioned upstream of the sensor with respect to a direction of travel of light along the optical path, wherein the first movable window is configured to move into the optical path in a deployed position for modifying light received from the target.

Abstract: An intravascular device includes an elongated body having a proximal end and a distal end, and a plurality of energy transmitting conduits extending within the elongated body. The distal ends of the energy transmitting conduits terminate at different axial locations along the distal end of the elongated body. In one embodiment, the number of energy transmission conduits is only two, such that the number of bends in the compound curve assumed by the distal end of the elongated body is only two, although the number of energy transmission conduits may be any suitable number.

Abstract: A medical device includes: an elongated member having a proximal end, a distal end, and a body extending between the proximal end and the distal end; wherein the elongated member comprises a tubular section having a plurality of slots extending into a wall of the tubular section, the plurality of slots comprising a first slot; and wherein the elongated member further comprises fillers respectively located in the slots, the filers comprising a first filler, wherein the first filler comprises a spongy material located in the first slot.

Abstract: A medical device includes: an elongated tube having a wall defining a lumen for the elongated tube, wherein the wall of the elongated tube comprises a first opening; and a first actuating element coupled directly or indirectly to the wall of the elongated tube; wherein at least a part of the first actuating element and the first opening of the wall are located at a same longitudinal position with respect to a longitudinal axis of the elongated tube; and wherein the first actuating element is configured to change size to induce stress and/or displacement at the wall of the elongated tube to cause the elongated tube to bend.

Abstract: A method of displaying a colorized luma image includes illuminating tissue under observation with illumination light and excitation light. A color image from reflectance of the illumination light and a fluorescence image produced by illuminating the tissue under observation with the excitation light are simultaneously detected at an image sensor to produce image data comprising both color image data and fluorescence image data. A luma image from the detected color image data is computed and the luma image is colorized based on the detected fluorescence image data. The colorized luma image is then displayed.

Abstract: Described are embodiments of methods and systems for using a removable data storage device to efficiently transfer medical data from a medical device to a remote server. In some embodiments, the medical device tracks transfer statuses of medical data stored on a local storage. A transfer status assigned to a data portion of the medical data may inform the medical device of whether that data portion needs to be transferred, has been transferred, or has been successfully ingested at the remote server. The medical device can use information stored on the removable data storage device in conjunction with the tracked transfer statuses to determine which portions of the stored medical data should be transferred to a physically coupled removable data storage device. After completing a data transfer process, the medical device can update transfer statuses of portions of medical data that was transferred to the removable data storage device.

Abstract: Methods and systems for characterizing tissue of a subject include acquiring and receiving data for a plurality of time series of fluorescence images, identifying one or more attributes of the data relevant to a clinical characterization of the tissue, and categorizing the data into clusters based on the attributes such that the data in the same cluster are more similar to each other than the data in different clusters, wherein the clusters characterize the tissue. The methods and systems further include receiving data for a subject time series of fluorescence images, associating a respective cluster with each of a plurality of subregions in the subject time series of fluorescence images, and generating a subject spatial map based on the clusters for the plurality of subregions in the subject time series of fluorescence images. The generated spatial maps may then be used as input for tissue diagnostics using supervised machine learning.

Abstract: Methods and systems for characterizing tissue of a subject include acquiring and receiving data for a plurality of time series of fluorescence images, identifying one or more attributes of the data relevant to a clinical characterization of the tissue, and categorizing the data into clusters based on the attributes such that the data in the same cluster are more similar to each other than the data in different clusters, wherein the clusters characterize the tissue. The methods and systems further include receiving data for a subject time series of fluorescence images, associating a respective cluster with each of a plurality of subregions in the subject time series of fluorescence images, and generating a subject spatial map based on the clusters for the plurality of subregions in the subject time series of fluorescence images. The generated spatial maps may then be used as input for tissue diagnostics using supervised machine learning.

Abstract: A filter includes a central filter region, the central filter region to transmit a first wavelength range, a peripheral filter region, the peripheral filter region to block a second wavelength range, and a transition filter region between the central and peripheral filter regions, the transition filter region to transmit or block the second wavelength range differently than the second wavelength range is to be transmitted or blocked in the central and peripheral filter regions. More generally, there may be “N” regions and up to N?1 transition regions.

Abstract: An optical tracker usable with a surgical object, the optical tracker includes a tracker frame including a mounting body, which defines an instrument engaging aperture having a longitudinal axis, and an offset body protruding proximally from the mounting body. The instrument engaging aperture is configured to receive a proximal region of the surgical instrument such that the longitudinal axis of the tracker is aligned with an axis of the surgical instrument. The tracker may further include a tracking array coupled to the tracker frame and comprising a mounting fixture and a plurality of LED emitters coupled thereto. The optical tracker may further comprise at least three apex points defined by the tracker frame that extend to a height above the LED emitters.

Abstract: An aspiration system comprises an aspiration catheter, an aspiration source fluidly coupled to the aspiration catheter to create an aspiration flow path between the aspiration catheter and the aspiration source, a pressurized fluid source, and a passive pressure oscillation assembly fluidly coupled between the pressurized fluid source and the aspiration flow path. The passive pressure oscillation assembly is configured for being operated between a normal mode that prevents fluid communication between the pressurized fluid source and the aspiration flow path, and an oscillatory mode that pulses fluid communication between the pressurized fluid source and the aspiration flow path. The passive pressure oscillation assembly is configured for being triggered to switch from the normal mode to the oscillatory mode in response to a clog in the aspiration catheter.

Abstract: A surgical arm is presented. The surgical arm comprises a first interface configured to receive a device for performing or assisting a surgical procedure and multiple adjustment members configured to adjust the surgical arm relative to a respective adjustment axis. The surgical arm further comprises at least two operating members configured to operate different ones of the adjustment members wherein the operating members are marked with different visual codings. Further a method for providing visual guidance for operating the surgical arm according to a pre-determined surgical approach is presented.

Abstract: A method of controlling display of a navigation view for surgical navigation is described. The method comprises obtaining a planned entry point and a planned target, obtaining a current orientation of a surgical instrument, determining a current entry point, and controlling display of a navigation view indicating at least a recommended entry point. The recommended entry point is instantaneously changed from the planned entry point to the current entry point, upon a distance between the planned entry point and the current entry point fulfilling a predefined condition. Also disclosed are a processor, a computer-readable medium and a data carrier signal.

Abstract: A method, a surgical registration device, a sensor device, a system, a computer program, a computer-readable medium and a data carrier signal are disclosed. The surgical registration device comprises a surface, an optical pattern on the surface, and an interface unit to attach to a tracking system. The method comprises obtaining an image of the surgical registration device, detecting the at least one optical pattern in the image, obtaining surface model data describing the surface, obtaining a location of the optical pattern with respect to the surface, determining, based on the detected optical pattern, the surface model data and the location of the optical pattern, a second pose of the surface, obtaining depth information describing three-dimensional coordinates of the surface and determining, based on the second pose, the surface model data and the depth information, a third pose of the surface of the surgical registration device.

Abstract: A device for collecting and processing bone fragments comprises a housing and a filter element disposed in the housing. The filter element at least partially defines a collection chamber for the collection of a composition comprising bone fragments. An inlet cap is releasably coupled to either the housing or to the filter element and configured to receive the composition. The inlet cap includes a body, an inlet port extending from the body and configured to be coupled to a surgical tool, and a spout extending from the body opposite the inlet port. The spout includes an injection port extending into the collection chamber of the filter element. A outlet cap is releasably coupled to the housing and is configured to be coupled to a vacuum source.

Abstract: Methods and systems for alignment of a subject for medical imaging are disclosed, and involve providing a reference image of an anatomical region of the subject, the anatomical region comprising a target tissue, processing the reference image to generate an alignment reference image, displaying the alignment reference image concurrently with real-time video of the anatomical region, and aligning the real-time video with the alignment reference image to overlay the real-time video with the alignment reference image. Following such alignment, the subject may be imaged using, for example, fluorescence imaging, wherein the fluorescence imaging may be performed by an image acquisition assembly aligned in accordance with the alignment.

Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

Abstract: The present teachings generally provide for a surgical navigation system for use with an x-ray imaging device. The x-ray imaging device acquires x-ray images of an anatomical structure of interest at an angular position. The surgical navigation system includes a localizer with a tracking sensor, a gravity vector sensor coupled to the tracking sensor, a tracking device configured to be coupled to the C-arm so as to be movable with the C-arm between a plurality of angular positions. The tracking device comprises a tracking element detectable by the tracking sensor. A computer processor is operatively coupled with the localizer and configured to implement an imaging routine that receives tracking data from the tracking sensor and a gravity vector from the gravity vector sensor, generating an image vector indicative of the angular position at which the x-ray image was acquired.