Abstract: The present invention discloses control catheters and methods for pulmonary suffusion and related therapies. The control catheter may comprise a control end, working end having a first balloon, a minor lumen, and a first and second major lumen. One method of the present invention involves introducing the working end of the catheter into a circulator system of the mammal, positioning the catheter into a desired first lobe pulmonary artery, inflating the minor balloon using the corresponding lumen, positioning the major balloon in the main pulmonary artery, and inflating the major balloon using the corresponding lumen. The method may comprise the additional step of infusing a chemical agent through the distal tip after the inflation of the minor balloon and the major balloon.